Researchers have conducted a study into whether a high-salt diet is associated with faster conversion from clinically isolated syndrome (CIS) to multiple sclerosis (MS) MS activity and disability. This was measured by urinary sodium concentration
The study, titled ‘Sodium intake and multiple sclerosis activity and progression in BENEFIT’, published by Annals of Neurology and Wiley Online library, was a randomised clinical trial comparing early versus delayed interferon beta-1b treatment in 465 patients with a CIS. Each patient provided a median of 14 spot urine samples throughout the five year follow up. The team of scientists estimated the 24-hour urine sodium excretion level at each time point using the Tanaka equations, and addressed whether sodium levels estimated from the cumulative average of the repeated measures were associated with clinical (conversion to MS, EDSS) and magnetic resonance imaging (MRI) outcomes.
Average 24-hour urine sodium levels were not associated with conversion to clinically-definite MS over the five year follow up. In addition, they were not associated with clinical or MRI outcomes.
The study’s author, Kathryn Fitzgerald ScD, Department of Neurology and Neuroimmunology, Johns Hopkins School of Medicine, Baltimore, MA, United States concluded: “Our results, based on multiple assessments of urine sodium excretion over five years and standardised clinical and MRI follow-up, suggest that salt intake does not influence MS disease course or activity.” This article is protected by copyright.
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Source: MS-UK (16/06/17)