Women with multiple sclerosis and people diagnosed with the condition at a younger age are more likely to have a benign course of
MS, remaining fully functional for decades, according to researchers at the School of Medicine and Biomedical Sciences in New York.
Disease modifying drugs were also found to help maintain this benign state.
The results of the study Factors Associated With Benign Multiple Sclerosis In The New York State MS Consortium (NYSMSC) have been published in the journal BMC Neurology.
Although the general recommendation is that newly diagnosed MS patients immediately start treatment, it is not known whether benign MS (BMS) patients might also benefit from earlier treatment with disease modifying drugs (DMDs).
Researchers analysed more than 6,258 patients enrolled in The New York State MS Consortium (NYSMSC) to study the prevalence of BMS, the prognostic factors associated with BMS, and whether DMDs can maintain a benign status in people diagnosed with BMS at baseline.
Because there is no consensus as to a definition of BMS, the researchers used three distinct but common criteria to identify this condition: 1) patients who had an Expanded Disability Status Scale (EDSS) equal to or lower than 2, and disease duration greater than 10 years; or, 2) patients with an EDSS of 3 or lower, and disease duration greater than 15 years; or, 3) patients with an EDSS of 3 or lower, but disease duration of 10 or more years.
Depending on the classification criteria used, 19.8% to 33.3% of patients were characterized as having BMS at the time of enrolment.
Findings showed that being female and younger age at disease onset were positive prognostic factors of having BMS at baseline. Conversely, African-American race and progressive MS at onset were negative prognostic factors, meaning that a lower percentage of patients with those characteristics had a disease that followed a benign course.
Investigators found that both DMD use and longer disease duration significantly predicted the maintenance of BMS status at follow-up. This protective effect was particularly obvious in patients who were taking DMD both at baseline and follow-up.
These findings suggest that early initiation and continued treatment with DMDs is beneficial for BMS patients, increasing their likelihood of maintaining a benign status.
Source: Multiple Sclerosis News Today © Copyright 2014 - 2016 BioNews Services, LLC (22/07/16)