The impact of flavonoids on fatigue had not previously been investigated in RRMS, so researchers conducted the randomised double-blind placebo-controlled feasibility study in patients diagnosed with RRMS and fatigue over a period of six weeks, which was published in the BMJ Journal.
Forty people with RRMS (10 men and 30 women) took part in the study. They were randomly assigned to a high or low flavonoid group for six weeks and their fatigue and fatigability were measured at three visits (weeks 0, 3 and 6). The results showed a small effect on fatigue and a moderate effect on fatigability. Participants were asked to rate their level of fatigue on a numerical rating scale through daily ‘fatigue texts’ rating their fatigue between 1-10 (10 being the worst). This was done at 10:00, 15:00 and 20:00 every day throughout the duration of the study.
Researchers reported seven adverse events (four control, three intervention), only one of which was possibly related and it was resolved.
From these findings researchers concluded that a flavonoid beverage demonstrates the potential to improve fatigue and fatigability in RRMS.
Source: MS-UK 06/03/19