Neuropsychiatric and psychological
In multiple sclerosis, gray matter atrophy is extensive, and cognitive deficits and mood disorders are frequently encountered.
It has been conjectured that focal atrophy is associated with emotional decline. However, conventional MRI has revealed that the pathological characteristics cannot fully account for the mood disorders.
Dr. Aiyu Lin and colleagues from the First Affiliated Hospital of Fujian Medical University used the voxel-based morphometry method to compare the difference in the clinical manifestations and imaging parameters of Chinese patients with multiple sclerosis and healthy controls.
Furthermore, our study is the first to apply the Repeatable Battery for the Assessment of Neuropsychological Status scale in Chinese patients with relapsing-remitting multiple sclerosis to evaluate cognitive function.
The researchers suggest that gray matter atrophy exists in relapsing-remitting multiple sclerosis, and the cingulate and frontal cortices of the dominant hemisphere are the most severely atrophic regions of the brain. Additionally, this atrophy is correlated with cognitive decline and emotional abnormalities. These findings are published in Neural Regeneration Research (Vol. 8, No. 21, 2013).
Article: " Regional gray matter atrophy and neu-ropsychologcal problems in relapsing-remitting multiple sclerosis," by Lin AY, Chen FY, Liu F, Li ZW, Liu Y, Lin SF, Wang XY, Zhu JT.
Source: Medical News Today © MediLexicon International Ltd 2004-2013 (13/08/13)
Summary: This large, new study from the UK has used responses gained via the web portal of the UK MS Register to investigate the depression and anxiety profiles of people with MS, and to determine if anxiety and depression are linked to stage of disease or other demographic factors. In the 4178 respondents, anxiety and depression rates were extremely high, with over half of patients scoring highly on anxiety and depression clinical rating scales.
Women with relapsing-remitting MS (RRMS) were more anxious than men with RRMS and women with other MS subtypes. Patients with secondary progressive MS suffered most from depression. The outcomes from studies of this type continue to shed light the extent of mental health problems in patients with MS and will highlight the need for better mental health care of patients.
Studies have found that people with Multiple Sclerosis experience relatively high rates of anxiety and depression. Although methodologically robust, many of these studies had access to only modest sample sizes (N<200). The aims of this study were to use responses gained via the web portal of the UK MS Register (N>4000) to: describe the depression and anxiety profiles of people with MS; to determine if anxiety and depression are related to age or disease duration; and to assess whether the levels of anxiety and depression differ between genders and types of MS.
From its launch in May 2011 to the end of December 2011, 7786 adults with MS enrolled to take part in the UK MS Register via the web portal. The responses to the Hospital Anxiety and Depression Scale (HADS) were collated with basic demographic and descriptive MS data provided at registration and the resulting dataset was analysed in SPSS (v.16).
The mean HADS score among the 4178 respondents was 15.7 (SE 0.117, SD 7.55) with a median of 15.0 (IQR 11). Anxiety and depression rates were notably high, with over half (54.1%) scoring ≥8 for anxiety and 46.9% scoring ≥8 for depression. Women with relapsing-remitting MS were more anxious than men with this type (p<0.001), and than women with other types of MS (p?=?0.017). Within each gender, men and women with secondary progressive MS were more depressed than men or women with other types of MS (p<0.001, p<0.001).
This largest known study of its kind has shown that anxiety and depression are highly prevalent in people with MS, indicating that their mental health needs could be better addressed. These findings support service planning and further research to provide the best care for people with MS to help alleviate these debilitating conditions.
Jones KH, Ford DV, Jones PA, John A, Middleton RM, Lockhart-Jones H, Osborne LA, Noble JG.
College of Medicine, Swansea University, Swansea, Wales, United Kingdom.
Source: PLoS One. 2012;7(7):e41910. Epub 2012 Jul 30 & Pubmed PMID: 22860028 PMCID: PMC3408498 (08/08/12)