While yoga seems to be effective in a number of neuropsychiatric disorders, the evidence of efficacy in multiple sclerosis remains unclear.
The aim of this review was to systematically assess and meta-analyze the available data on efficacy and safety of yoga in patients with multiple sclerosis.
Medline/PubMed, Scopus, the Cochrane Central Register of Controlled Trials, PsycINFO, CAM-Quest, CAMbase, and IndMED were searched through March 2014.
Randomized controlled trials (RCTs) of yoga for patients with multiple sclerosis were included if they assessed health-related quality of life, fatigue, and/or mobility. Mood, cognitive function, and safety were defined as secondary outcome measures.
Risk of bias was assessed using the Cochrane tool. Seven RCTs with a total of 670 patients were included.
Evidence for short-term effects of yoga compared to usual care were found for fatigue (standardized mean difference [SMD] = −0.52; 95% confidence intervals (CI) = −1.02 to −0.02; p = 0.04; heterogeneity: I2 = 60%; Chi2 = 7.43; p = 0.06) and mood (SMD = −0.55; 95%CI = −0.96 to −0.13; p = 0.01; heterogeneity: I2 = 0%; Chi2 = 1.25; p = 0.53), but not for health-related quality of life, muscle function, or cognitive function.
The effects on fatigue and mood were not robust against bias. No short-term or longer term effects of yoga compared to exercise were found. Yoga was not associated with serious adverse events. In conclusion, since no methodological sound evidence was found, no recommendation can be made regarding yoga as a routine intervention for patients with multiple sclerosis.
Yoga might be considered a treatment option for patients who are not adherent to recommended exercise regimens.
Source: PLOS | One (13/11/14)
A new study has found that people with multiple sclerosis may reduce perceived fatigue and increase mobility through a series of combined strength training and fitness exercises.
The research from the Miguel Hernández University of Elche, supervised by Professor Raúl Reina, aimed to analyze the effects of strength training on the fatigue that MS patients suffer. A total of 19 participants (5 men and 14 women) were split into two groups. Most took part in a 12-week training program, whilst others were included in a control group. The research was conducted in collaboration with the Neurology Department of Elche General Hospital.
A first phase of general fitness was followed by a personalized intervention program based on each patient’s maximum force. The scientists assessed the effects of training and found that the experiment group gained "a fair amount" of functionality while the control group remained stable.
One patient, who was diagnosed the illness in 2007, says she has noticed improvements in her daily routine: “I was used to a life with limitations and now I can pick up my son and go with him to the park on foot."
The training and data collection process took place on campus, both at the sports facilities and the university’s Sport Research Centre. Meanwhile, perceived fatigue was registered daily, weekly and monthly through specific questionnaires. Each patient’s muscle strength was assessed by isokinetic dynamometry and functional tests.
The study also includes an analysis of motivational aspects and an interview on the perception of the effects of sport. This part is especially interesting as it shows an improvement of the participants’ quality of life, although the University will continue working with the MS patients to see the long term effects.
Source: Science 2.0 © 2014 ION Publications LLC (01/10/14)
Specialised programme improved quality of life, decreased pain and fatigue.
Paula Meltzer was only 38 when out of nowhere everything she looked at was blurry. For the single mother, who had a lucrative career as a gemologist and spent hours examining valuable pieces of jewelry, it seemed as if – in a split second – her life changed.
At first doctors thought Meltzer had a brain tumor. What they determined after further tests, however, was that she had multiple sclerosis, an autoimmune disease that affects the brain and central nervous system and was causing optic neuritis, an inflammation of the optic nerve that can cause a partial or complete loss of vision.
“I was living independently, doing my job, taking care of my child and then I had to look to my parents to take care of me,” Meltzer said.
Almost two decades later, Meltzer, out of a wheelchair and walking without a cane, was one of 14 women with moderate disability due to MS who participated in a pilot trial conducted by the Rutgers School of Health Related Professions. A specially-designed yoga program for these MS patients not only improved their physical and mental well-being but also enhanced their overall quality of life.
“I felt like I became steadier and stronger in my core,” Meltzer said. Prior to yoga, she described herself as a “wall walker,” someone who felt safer holding onto the wall in order to get around. “To be able to stand on one leg and feel balanced is amazing.”
Susan Gould Fogerite, director of research for the Institute for Complementary and Alternative Medicine in the School of Health Related Professions, said that although there is widespread evidence that yoga is being used as a form of exercise by those with MS, much of the feedback has been anecdotal and there isn’t much empirical data regarding its safety and efficacy.
This is why she and her colleagues, Evan Cohen and David Kietrys, physical therapists and associate professors in the School of Health Related Professions at Stratford, decided to undertake the small pilot study, believing that a specialized yoga program for MS patients – which incorporates mind, body and spirit – would be beneficial to everyday living.
What they discovered at the end of the eight-week trial was that those who participated were better able to walk for short distances and longer periods of time, had better balance while reaching backwards, fine motor coordination, and were better able to go from sitting to standing. Their quality of life also improved in perceived mental health, concentration, bladder control, walking, and vision, with a decrease in pain and fatigue.
“Yoga is not just exercise, it is a whole system of living,” said Fogerite, an associate professor, who, along with Kietrys, will present the results on September 26 at the Symposium on Yoga Research at the Kripalu Institute in Massachusetts. “The panel of experts who advised us on the trial wanted to make sure that we provided a fully integrated program that included philosophy, breathing practices, postures, relaxation and meditation.”
The yoga pilot trial was held at Still Point Yoga Center in Laurel Springs, a southern New Jersey town close to Philadelphia. Of the 72 individuals who were interested in participating, only 16 were eligible based on medical and other criteria and availability. Of those, 15 were enrolled and 14 completed the program after one person had to withdraw because of an unrelated health problem.
Meltzer and the other women who participated in the trial ranged in age from 34 to 64. Some had been diagnosed with MS within the last two years while others had been living with the illness for up to 26 years. For 90 minutes, twice a week for two months, they practiced techniques and exercises that would improve their posture, help to increase stamina, and teach them how to relax and focus.
“This study, I hope, is one of many that will give us the clinical information we need,” said Fogerite. “Yoga is not currently being widely prescribed for people with MS, although it might turn out to be a very helpful treatment.”
The yoga practices were done by the women in the study sitting, standing, or lying on yoga mats, and using metal folding chairs situated close to the wall to provide them with more support.
“What was so nice about this experience was that although everyone was at a different level of the disease, we felt like we were all together, so I think the comraderie helped,” said Meltzer. “And it wasn’t just about gaining more mobility and balance in our legs but our arms and necks felt stronger as well.”
Fogerite said a larger randomized controlled trial would be needed to determine whether yoga could be used as a prescribed treatment for individuals with moderate disability due to MS. More than 2.3 million people – two to three times more women than men – throughout the world are diagnosed with this disease which can cause poor coordination, loss of balance, slurred speech, tremors, numbness, extreme fatigue and problems with memory and concentration.
“When I was first diagnosed I no longer felt safe in my own body,” Meltzer said. "I didn’t trust my body at all. What the program did was really bring that trust back.”
Source: Rutgers Copyright 2014, Rutgers, The State University of New Jersey (02/09/14)
Multiple sclerosis (MS) patients who would benefit the most from an increase in physical activity were, unfortunately, those for whom an intervention designed to boost it was least effective, a researcher said here.
In a secondary analysis of data from an earlier, overall successful trial of an Internet-based exercise intervention, factors associated with the strongest responses included mild versus moderate disability, body weight in the normal range versus obesity, and relapsing-remitting versus progressive MS, according to Robert Motl, PhD, of the University of Illinois in Urbana-Champaign.
There is "value in modifying and refining interventions" to improve their chances of success in difficult populations, he suggested at the joint meeting of the Consortium of Multiple Sclerosis Centers and the Americas Committee for Treatment and Research in Multiple Sclerosis.
Separately, another analysis of the same trial data indicated that, in the overall study sample, the improvements seen in measures of physical activity were accompanied by reductions in time spent sitting.
Rachel Klaren, a graduate student in Motl's laboratory, reported that mean sitting time among all study participants (including dropouts) was lower by 1.6 hours per day compared with a wait-listed control group; and among those completing the study per protocol, the difference was 2.1 hours per day.
The results confirmed that participants did indeed get up out of their chairs to achieve the increased step counts seen in the primary study results, reported at the CMSC-ACTRIMS meeting in 2013.
Motl and colleagues had developed a 6-month intervention geared to increasing physical activity in MS patients. It included a website providing information on how MS patients can become more physically active using social cognitive therapy techniques, as well as one-on-one live video coaching conducted over the Internet. Participants wore pedometers and had goals for the number of steps, recording their actual step counts in a diary.
At the 2014 meeting, Motl explained that physical activity is known to be beneficial in preserving mobility for MS patients, which typically diminishes over time even in those who remain in the relapsing-remitting phase.
The trial randomized 82 patients either to the intervention or to a wait-listed control. While on the wait-list, participants received no encouragement or coaching; they then entered the program at the trial's conclusion.
Who Responds, Who Doesn't
Overall, mean step counts increased from baseline by nearly 40% in the intervention group. But Motl said that the investigators noted that not every participant showed such an increase. In fact, some had marked decreases.
Relative to the wait-listed controls, only those in the intervention group with mild disability on the basis of Expanded Disability Status Scale scores showed increases in step counts, whereas the intervention had no effect for those classified with moderate disability (P<0.01 for the effect of disability status).
Similarly, the intervention was effective only in those with relapsing-remitting disease, not in those with progressive forms of MS (P<0.01 for the effect of clinical course) -- and it was effective only for those with body mass index values of 25 kg/m2 or less, not for those with higher values (P<0.05 for the effect of obesity status).
As it happens, the subgroups not benefiting from the intervention were those at the greatest risk for continued or accelerated disability progression, and therefore those for whom an increase in physical activity would have the greatest health benefit. Motl concluded that his, or other interventions, may need to be tailored more specifically to these patients to increase the chances of success.
Other factors, including whether patients were taking disease-modifying drugs or medications for specific MS symptoms, did not affect the intervention's impact, Motl indicated.
Effect on Sedentarism
Klaren noted that time spent sitting "has been described as 'the new smoking'" because of its adverse effects on a host of health outcomes.
Although the increase in step counts seen in the trial's primary results might logically entail a commensurate decrease in sitting times, it can't be assumed. Consequently, Klaren analyzed data on sitting time specifically collected in the trial.
As part of the baseline and 6-month follow-up evaluations, participants were asked to estimate their average daily time spent sitting down over the past 7 days. The analysis covered 70 participants who had provided baseline data (intent-to-treat sample), of whom 13 did not complete the intervention.
In the overall group and after adjusting for baseline differences, the mean daily sitting time in the intervention group at follow-up was 7.2 hours (SE 3.3), compared with 8.8 (SE 3.3, P<0.05) for the wait-listed controls.
For the per-protocol group, mean daily sitting time at follow-up was 6.8 hours (SE 3.5) with the intervention versus 8.9 (SE 3.5, P<0.05) for controls, Klaren reported.
She said these were the first data specifically addressing the effect on sitting time of an exercise intervention in MS patients.
Next steps, she added, would be to examine whether reductions in sitting time really do lead to demonstrable health benefits, and to identify factors associated with sedentarism in MS patients.
The study was supported by the National Multiple Sclerosis Society.
Motl reported relationships with Biogen Idec and Acorda. Klaren declared she had no relevant financial interests.
Primary source: Consortium of Multiple Sclerosis Centers and the Americas Committee for Treatment and Research in Multiple Sclerosis
Source reference: Motl R, et al, "Does the effect of a physical activity behavior intervention vary by clinical characteristics of people with multiple sclerosis?" CMSC-ACTRIMS 2014; Abstract RH05.
Additional source: Consortium of Multiple Sclerosis Centers and the Americas Committee for Treatment and Research in Multiple Sclerosis
Source reference:Klaren R, et al "Efficacy of a behavioral intervention for reducing sedentary behavior in people with multiple sclerosis" CMSC-ACTRIMS 2014; Abstract RH04.
Source: MedPage Today © 2014 MedPage Today, LLC (04/06/14)
Some people are content to sit back and relax when they retire, maybe traveling or working in their gardens.
Others want to turn their talents toward helping others. That was true of Jana Gasiorkiewicz.
About seven months ago, Gasiorkiewicz became a certified yoga instructor. Several months ago, she launched her Yoga on a Chair classes.
But her practice targets patients with multiple sclerosis and similar medical conditions. The classes are conducted on chairs “because so many people can’t get down on the mat,” she explains.
“You don’t need the stamina (to stand),” she said. “Without overtaxing those already weakened limbs and your heart, you can bring some movement and build some heat without exhausting yourself.”
Gasiorkiewicz retired in 2011 after working for 20 years for the Kenosha Unified School District. The last 11 years were spent teaching French at Bradford High School. She has been teaching one French class at the University of Wisconsin-Parkside since September.
After retiring, she said she had more time and started going to yoga classes at YogaRoots Racine, 518 College Ave., in Downtown Racine.
Gasiorkiewicz’s daughter, Suzanne Selmo, had become a yoga therapist in California. Gasiorkiewicz, 65, received her instructor certification in July. But then the question became whom would she teach?
She said a friend’s husband has Parkinson’s disease, and he benefited from yoga.
“It gave me the idea to target my practice to a particular audience,” Gasiorkiewicz said. “When I looked into it, I found there were many more MS patients than Parkinson’s patients.”
Multiple sclerosis is an often-disabling central nervous system disorder. Symptoms range from abnormal fatigue to memory, attention and vision problems, according to the National Multiple Sclerosis Society. Some patients may suffer some form of paralysis, or need help from a cane or crutches to work, according to the organization.
Because people with MS may have a limited range of motion, or may not be able to lie on the floor on mats, Gasiorkiewicz teaches her classes on chairs.
A relative with MS died about six years ago. And Gasiorkiewicz said she learned a few years ago that a former coworker with MS had died.
“Those two women — their lives were so changed by MS. Those reasons were in the back of my mind,” she said.
Some patients have mild symptoms. Others, she said, are in wheelchairs. Two participants, a married couple from Kenosha, have said they both benefit from the classes. But only the wife has MS.
“For me, it’s strengthening, flexibility, balance, stress reduction,” she said. “If they would try it consistently, after a few months they would see the benefits would warrant setting aside a little money or time.”
Source: Journal Times © Copyright 2014, Journal Times (26/02/14)
Study finds short bouts of moderately intense activity can have big impact on tiredness levels of people with MS.
Multiple sclerosis sufferers can reduce the fatigue that accompanies their condition by undertaking short bursts of moderately intense exercise, such as walking or cycling, according to new research.
Participating in such activities even for a few minutes boosted their quality of life and reduced their extreme tiredness, patients reported in a trial of 120 people with MS living in Sheffield.
"It seems illogical to turn to exercise as a way of managing fatigue but the results showed that a pragmatic programme based on short bouts of moderate intensity exercise can really help improve symptoms and quality of life", said Professor John Saxton, who led the research while at Sheffield Hallam University but who is now at the University of East Anglia.
For 12 weeks, 60 of the 120 participants undertook five bursts of three minutes of exercises, either in a gym or at home, with two-minutes rests in between. As the trial progressed, they were encouraged to increase the busts to four minutes or take shorter rest breaks. The other 60 received standard NHS care for their condition, which did not include exercise.
Those who had done the physical activity had "significantly lower" levels of fatigue than those who had not. They also reported "long-term improvements in emotional wellbeing, social function and overall quality of life", which lasted for up to nine months, according to the MS Society, which funded the study. The exercise regime was also more cost-effective than normal NHS care.
The charity believes exercise could help the UK's 100,000 or so MS patients.
"Fatigue in MS is an incredibly common but troubling symptom that can hugely affect an individual's quality of life. For many people with MS this programme could be a cost-effective treatment option", said Ed Holloway, its head of care and services research.
Source: The Guardian © 2014 Guardian News and Media Limited (15/01/14)
Objectives: Yoga has been found to be effective for addressing problems with strength, flexibility, balance, gait, anxiety, depression, and concentration. Varying degrees of these problems occur in individuals with multiple sclerosis (MS). This study examined the effects of a comprehensive, 4-month yoga program on strength, mobility, balance, respiratory function, and quality of life for individuals with MS.
Methods: Twenty four individuals with MS participated in an intensive Ananda Yoga training followed by 17 weeks of home practice.
Results: Significant improvements in functional strength, balance, and peak expiratory flow and a trend toward improvements in mental health and quality of life outcomes were detected following the intervention.
Conclusions: The results of this exploratory study suggest that yoga can have a positive impact on physical functioning and quality of life for persons with mild to moderate MS.
Salgado BC, Jones M, Ilgun S, McCord G, Loper-Powers M, van Houten P.
Department of Physical Therapy, California State University, Sacramento, CA.
Sources: Int J Yoga Therap. 2013;23(2):27-38 & Pubmed PMID: 24165521 (08/11/13)
Aerobic exercise can boost memory in people with multiple sclerosis (MS) by up to 54 per cent, a new study has found.
The study led by Victoria Leavitt and James Sumowski, from Kessler Foundation, US, provides the first evidence for beneficial effects of aerobic exercise on brain and memory in individuals with MS.
Hippocampal atrophy seen in MS is linked to the memory deficits that affect approximately 50 per cent of individuals with MS, researchers said.
Despite the prevalence of this disabling symptom, there are no effective pharmacological or behavioural treatments.
"Aerobic exercise may be the first effective treatment for MS patients with memory problems," said Leavitt, research scientist in Neuropsychology & Neuroscience Research at Kessler Foundation.
"Moreover, aerobic exercise has the advantages of being readily available, low cost, self-administered, and lacking in side effects," Leavitt said.
Researchers said no beneficial effects were seen with non-aerobic exercise.
Leavitt noted that the positive effects of aerobic exercise were specific to memory; other cognitive functions such as executive functioning and processing speed were unaffected.
The study's participants were two MS patients with memory deficits who were randomised to non-aerobic (stretching) and aerobic (stationary cycling) conditions. Baseline and follow-up measurements were recorded before and after the treatment protocol of 30-minute exercise sessions 3 times per week for 3 months.
Data were collected by high-resolution MRI (neuroanatomical volumes), fMRI (functional connectivity), and memory assessment.
Aerobic exercise resulted in a 16.5 per cent increase in hippocampal volume, a 53.7 per cent increase in memory, and increased hippocampal resting-state functional connectivity.
Non-aerobic exercise resulted in minimal change in hippocampal volume and no changes in memory or functional connectivity.
"These findings clearly warrant large-scale clinical trials of aerobic exercise for the treatment of memory deficits in the MS population," said Sumowski, research scientist in Neuropsychology & Neuroscience Research at Kessler Foundation.
Source: The India Express Copyright © 2013 The Indian Express ltd (04/11/13)