About MS  > MS news and research  > hormones
About MS

What is MS?

MS symptoms

Managing your MS

Effects of MS

MS news and research

Bacteria and viruses

Biomarkers and microRNA

CCSVI

Cognition

Diet

Drugs

Endo-parasites and helpful organisms

Environmental factors

Ethnic groups, geographical regions and MS

Exercise

Genetics

Hormones

Immune cells

Inflammation, lesions & 'black holes'

Medical imaging

MS Symptoms research

Multiple Sclerosis (etiology)

Myelin

Nerves, brain cells and spinal cord

Paediatric MS

Pain

Potential viral causes

Quality of life

Retroviruses

Sex and MS

Stem cells

Technology

Types of MS

Vaccinations

Vitamin D

News and research archive

World MS Day

Other support

Donate with JustGiving

Latest Tweets

Hormones

 

Risk of MS increased by low testicular function(21/08/14)

Testicular hypofunction and multiple sclerosis risk: A record-linkage study.

Pakpoor J, Goldacre R, Schmierer K, Giovannoni G, Goldacre MJ.

Abstract

The influence of gonadal hormones on multiple sclerosis is not well characterised and has thus far been investigated primarily in animal models or as a proposed therapeutic approach.

We investigated a potential association between testicular hypofunction, as a proxy for low testosterone levels, and multiple sclerosis risk through analysis of linked English national Hospital Episode Statistics from 1999 to 2011.

We report a strong positive association between testicular hypofunction and subsequent multiple sclerosis, rate ratio 4.62 (95% confidence interval 2.3-8.24, p<0.0001).

Future work should aim more directly to elucidate the relationship between testosterone levels and MS in both males and females.

Source: ANN NEUROL 2014. © 2014 American Neurological Association & Pubmed 25131454 (21/08/14)