Multiple Sclerosis UK
  Welcome to The MS-UK MS Forum  MS-UK Website   Free Information & Advice Line 0800 783 0518

Forum Home Forum HomeAbout MSLet's Talk MS
  New Posts New Posts RSS Feed - does methanol (wood alcohol) cause MS?
  FAQ FAQ  Forum Search   Events   Register Register  Login Login

Welcome to the MS-UK MS Forum.     Please Note to POST on the Forum you MUST register as a member.     If you need help using the forum please email squiffy@ms-uk.org

does methanol (wood alcohol) cause MS?

 Post Reply Post Reply Page  123>
Author
Message
RichMurray View Drop Down
Been here a while
Been here a while
Avatar

Joined: 03 Jul 2013
Location: United States
Status: Offline
Points: 17
Post Options Post Options   Thanks (0) Thanks(0)   Quote RichMurray Quote  Post ReplyReply Direct Link To This Post Topic: does methanol (wood alcohol) cause MS?
    Posted: 03 Jul 2013 at 8:07am
 Geek in case anyone is interested -- plenty of evidence since idea was presented in fall 2007 --

EFSA faces robust evidence -- methanol from aspartame and cigarettes is
made into reactive formaldehyde inside cells by ADH1 enzyme in 20 human
tissues -- comprehensive WC Monte paradigm: Rich Murray 2013.05.03




Edited by Squiffy - 03 Jul 2013 at 10:02am

within the fellowship of service,
Rich Murray
http://rmforall.blogspot.com
Back to Top
Squiffy View Drop Down
Moderator Group
Moderator Group
Avatar
Moderator

Joined: 25 Jan 2013
Location: MS-UK
Status: Offline
Points: 767
Post Options Post Options   Thanks (0) Thanks(0)   Quote Squiffy Quote  Post ReplyReply Direct Link To This Post Posted: 03 Jul 2013 at 10:03am
Hi Rich and welcome to the MS-UK Forum.

Thank you for posting this interesting article.
"Don't think of me as being crazy. Think of me as abstaining from sanity..............."
Back to Top
RichMurray View Drop Down
Been here a while
Been here a while
Avatar

Joined: 03 Jul 2013
Location: United States
Status: Offline
Points: 17
Post Options Post Options   Thanks (0) Thanks(0)   Quote RichMurray Quote  Post ReplyReply Direct Link To This Post Posted: 05 Jul 2013 at 7:27am
11% of aspartame is methanol, which becomes free floating formaldehyde inside human cells -- methanol also in cigarettes and canned fruits and vegetables: Rich Murray 2013.07.04


The Woodrow C. Monte methanol/formaldehyde toxicity paradigm is that
concentrations of ADH1 enzyme, well known to exist inside blood vessel
wall cells in specific tissues, quickly turn methanol into
formaldehyde inside the vessel cells, in humans only -- the highly
reactive formaldehyde diffuses to penetrate adjacent tissue cells,
binding to DNA, RNA, and proteins, attracting macrophages, which die,
creating complex, expanding micro lesions, leading to many modern
"diseases of civilization", Alzheimer's, arthritis, diabetes, multiple
sclerosis, lupus -- as well as later cancers -- also serious birth
defects in the fetal brain in the fourth week of pregnancy, spinal
bifida and autism.

Aspartame is 11% methanol, 22 mg per can of diet drink -- similar
levels of methanol come from wood and cigarette smoke, heated and
canned fruits juices vegetables, fermented and smoked foods, some
wines and liquors, vehicle fuels, many cleaners and solvents, chemical
medical autopsy mortuary facilities, heated wood in particleboard and
paper factories, and more.


similar macular harm in multiple sclerosis as from formaldehyde made
by ADH enzyme inside retina capillary walls from methanol, Prof.
Woodrow C. Monte text "While Science Sleeps" 2012 Jan -- some quotes
re retina harm: Rich Murray 2012.05.10
http://rmforall.blogspot.com/2012/05/similar-macular-harm-in-multiple.html
http://health.groups.yahoo.com/group/aspartameNM/message/1647


aspartame impairment of spatial cognition and insulin sensitivity in
mice, focus on phenylalanine and aspartate [ methanol also crosses
placenta into fetus, turning into teratogenic formaldehyde], Kate S.
Collision et al, PLoS One 2012.04.03: Rich Murray 2012.04.29
http://rmforall.blogspot.com/2012/04/aspartame-impairment-of-spatial.html
http://health.groups.yahoo.com/group/aspartameNM/message/1645


WC Monte submits submits robust evidence for multiple sclerosis, which he concludes proves methanol to be the proximate toxic cause, since ADH1 enzyme is within the cells of the inner linings of brain blood vessels, the Purkinje cells of the vermis of the cerebellum, and rods and cones of the retina -- ADH1 quickly turns methanol into free floating formaldehyde within these cells, disrupting the blood brain barrier...

Methanol (wood alcohol), from aspartame, cigarette smoke, and unfresh fruits juices vegetables cut up and preserved wet at room temperature in sealed cans jars plastic containers, goes to all parts of the body every minute with the blood flow, with half-life 3 hours -- it readily enters all cells in body and fetus, just as does ethanol.

Humans are uniquely vulnerable, as their cells lack the enzymes that in all other animals prevent ADH1 enzyme from rapidly making methanol into free floating formaldehyde right inside the cells of 20 specific tissues, including the islets of Langerhans in the pancreas, where insulin is produced. As free floating formaldehyde, molecule by molecule, rapidly binds firmly on both sides to the nearest DNA, RNA, and large proteins in a cell, the cell malfunctions and dies. Gradually the chronic low level toxicity impairs the production and functioning of insulin.

#6 diabetes 2 risk high for 2 cans aspartame diet drink weekly 14
years 66K women study, Guy Fagherazzi et al AJCN 2013 Jan -- methanol
(cigarettes, aspartame) formed into formaldehyde inside cells in
pancreas by ADH1 enzyme, WC Monte paradigm: Rich Murray 2013.02.13

http://rmforall.blogspot.com/2013/02/6-diabetes-2-risk-high-for-2-cans.html

ADH1 is "unusually highly concentrated" in the million tiny "isles of Langerhans" in the pancreas, where the beta cells make insulin -- cigarette use correlates with diabetes 2 risk, with a doubling of risk for smoking over a pack daily.
[ page 172, "While Science Sleeps", 2012 January, Prof. Woodrow C. Monte, Food Science and Nutrition, Arizona State University, retired 2004 ]

WhileScienceSleeps.com includes free online archive of 745 full text medical research references:

http://www.whilesciencesleeps.com/references/

http://www.whilesciencesleeps.com/pdf/637.pdf 5 pages

Baehler R., Pestalozzi D., Hess M., Von Wartburg JP.
Immunohistochemical localization of alcohol dehydrogenase in human kidney, endocrine organs and brain.
Pharmacol Biochem Behav. 1983;
18 Suppl 1:55-9 1983;18(Suppl 1):55-9.

http://www.whilesciencesleeps.com/pdf/648.pdf 12 pages

Willi C., Bodenmann P., Ghali WA., Faris PD., Cornuz J.
Active smoking and the risk of type 2 diabetes: a systematic review and meta-analysis.
JAMA 2007;298(22):2654-64.

http://www.whilesciencesleeps.com/pdf/283.pdf 5 pages

Wei M, Gibbons L, Mitchell T, Kampert J, Blair S.
Alcohol intake and incidence of type 2 diabetes in men.
Diabetes Care 2000;23(1):16-21. Ming Wei mwei@cooperinst.org

Many of these diseases, including diabetes 2, are twice as harmful for those who never drink ethanol, compared to those who have just one standard drink a day, due to the inhibition by ethanol of formation of formaldehyde from methanol by ADH1.

Many people are protected by ethanol in their blood from fermentation by bacteria in the GI tract.



The public EFSA session on aspartame safety on April 9 for 5 hours included an audience of about 50 experts and 10-20 ESFA staff in Brussels.

The release of the final EFSA review on aspartame safety will be delayed from April 15 to November, 2013.

Extremely cogent multiple lines of robust evidence were briefly described
that strongly support the methanol formaldehyde toxicity paradigm of Prof. Woodrow C. Monte, Prof. Food Science and Nutrition, Arizona State University, retired 2004 -- supported by an online archive of 745 free full text medical research references at www.WhileScienceSleeps.com .

It is clear that methanol is far more dangerous for chronic low level exposures than realized since 1890.

Major sources include the smoke from a pack of cigarettes, 40 mg methanol,the same as from 2 cans aspartame diet drink. It now seems likely that most cigarette diseases are actually methanol toxicity...

Methanol stays in the blood with a half-life of 3 hours, reaching every part of the body and the fetus with the bloodstream, and readily entering
all cells.

Humans are uniquely vulnerable to methanol formaldehyde toxicity, as they lack a functioning catalase enzyme system, that in all other creatures serves to protect each cell against the rapid conversion of methanol into free floating formaldehyde right inside the cells of 20 specific tissues that have high levels of ADH1 enzyme.

The effects are used to good advantage in embalming and disinfection, as formaldehyde immediately bonds to and impairs DNA, RNA, and proteins, permanently disrupting cell biochemistry, cell by cell, as long as methanol is ingested -- leading to 20 specific chronic modern novel "diseases of civilization", that progress slowly and erratically, according to the ingestion of methanol from a variety of modern sources:

smoke from cigarettes, wood, and peat;

since 1983, aspartame, including from most chewing gums;

fresh tomatoes and black currants;

unfresh fruits juices vegetables cut up and preserved wet at room temperature in sealed cans jars plastic containers;

jams jellies marmalades;

smoked fermented spoiled foods;

many dark wines and liquors;

work at paper and wood factories, mortuaries, medical and chemical facilities;

Research since 2012 specifically shows the presence of formaldehyde bonded to cellular macromolecules inside cells after methanol ingestion -- the paradigm will be confirmed in detail very quickly, as science exponentially explores this simple breakthrough.

This presents the world food industry with an unprecedented opportunity to serve the huge public good by collaborating vigorously to eliminate all methanol exposures from foods and beverages. The Net guarantees that the news and evidence will spread explosively everywhere.


Paul Thomas MD Pediatrics & Integrative Medicine, Portland OR, praises
"While Science Sleeps" at Amazon.com -- WC Monte paradigm of methanol
formaldehyde toxicity via ADH1 enzyme in 20 human tissues, including fetus: Rich Murray 2013.04.03
http://rmforall.blogspot.com/2013/04/paul-thomas-md-pediatrics-integrative.html


autism as a birth defect from epigenetic methylation by formaldehyde made from methanol by ADH1 enzyme inside Purkinje cells in vermis in cerebellum and in inner walls of brain blood vessels -- Prof. WC Monte paradigm: Rich Murray 2013.04.26
http://rmforall.blogspot.com/2013/04/autism-as-birth-defect-from-epigenetic.html


highly competent, pithy analysis of aspartame cancer study by Eva S.
Schernhammer at Harvard, William R. Ware, PhD, showing relevance of
Woodrow C. Monte methanol-formaldehyde toxicity paradigm: Rich Murray
2012.12.03
http://rmforall.blogspot.com/2012/12/highly-competent-pithy-analysis-of.html


Prof. Resia Pretorius letter re aspartame to EJCN cites Prof. Woodrow C.
Monte "While Science Sleeps" text, re methanol/formaldehyde toxicity
paradigm: Rich Murray 2012.05.21
http://rmforall.blogspot.com/2012/05/prof-resia-pretorius-letter-re.html


Aspartame: The hidden danger [methanol/formaldehyde] in our midst and how it kills us, 12 page review of While Science Sleeps text (Woodrow C Monte), International Health News, whole June issue, Editor: William R Ware PhD: Rich Murray 2012.06.08
http://rmforall.blogspot.com/2012/06/aspartame-hidden-danger.html


Table 5.2 is the key chart -- ADH1 enzyme at high levels in 20 tissues in body and fetus makes methanol into formaldehyde right inside cells, initiating over 20 human diseases, with full text references, WC Monte paradigm: Rich Murray 2013.03.21
http://rmforall.blogspot.com/2013/03/table-52-is-key-chart-adh1-enzyme-at.html    
http://health.groups.yahoo.com/group/aspartameNM/message/1734


"As a matter of course, every soul citizen of Earth has a priority to
quickly find and positively share evidence for healthy and safe food,
drink, environment, and society."


within the fellowship of service,

Rich Murray,
MA Boston University Graduate School 1967 psychology,
BS MIT 1964 history and physics,
254-A Donax Avenue, Imperial Beach, CA 91932-1918,
rmforall@gmail.com,
505-819-7388 cell,
619-623-3468 home,
http://rmforall.blogspot.com
Back to Top
RichMurray View Drop Down
Been here a while
Been here a while
Avatar

Joined: 03 Jul 2013
Location: United States
Status: Offline
Points: 17
Post Options Post Options   Thanks (0) Thanks(0)   Quote RichMurray Quote  Post ReplyReply Direct Link To This Post Posted: 08 Jul 2013 at 6:11am
Woodrow C. Monte multiple sclerosis lecture video gets 7 positive Amazon.com reviews by patients and experts: Rich Murray 2013.07.06 
http://rmforall.blogspot.com/2013/07/woodrow-c-monte-multiple-sclerosis.html


Customer Reviews at Amazon.com:
Solving the Mystery of Multiple Sclerosis: Is your Diet Secretly Poisoning You? (DVD)
$ 25   145 minutes  2010.05.07 [ not copy protected ]
Woodrow C. Monte, PhD
Prof. Emeritus, Food Science and Nutrition,
Arizona State University (retired 2004)
www.WhileScienceSleeps.com

8 Reviews
5 star:         (8)
4 star: (0)
3 star: (0)
2 star: (0)
1 star: (0)
 
Average Customer Review
5.0 out of 5 stars (8 customer reviews)
 
Most Helpful First | Newest First

11 of 11 people found the following review helpful
5.0 out of 5 stars
Honest and Accurate Information, May 21, 2010
By Cori Brackett (Tucson, AZ) 

Dr. Monte belongs to a class of much needed doctors.
He is a research scientist who passionately believes in investigating the scientific truth behind an issue and then sounding the alarm in an entertaining and plausible way. History is littered with examples of how we fell into murky waters of disease without realizing what we were doing; take lead, x-rays and thalidomide as just a few examples.
In this DVD, Dr. Monte takes a magnifying glass to the problem of MS and other Diseases of Civilization, and elegantly explains the issue in a way from which both laypeople and scientists can learn.
This is a very important DVD.
When you're done with it, you'll want to scream this information from the rooftops.
Dr. Monte is encouraging people to copy this DVD freely and give them to people with MS.
Having been diagnosed with MS myself, I can attest to the importance of this, as well as the difficulty with which we try to plow through the bucket loads of misinformation searching for something, anything, that might offer relief.

I have been working with Dr. Monte for a while now, and first began following his dietary suggestions a little over a year ago. 
Having produced the documentary, Sweet Misery: A Poisoned World, I was well aware of the dangers of methanol.
However, I did not know of all of the sources of methanol in the diet.
Once I began following, Dr. Monte's protocol, some nagging, remaining symptoms left me and I have been fully symptom-free ever since.
 
Please, PLEASE get this video, for yourself and your loved ones, and give a copy to anyone with MS who you know who would benefit from this information.
It's revolutionary.
Science has been in the dark for too long as to the cause of MS.
Dr. Monte's well-thought out and careful presentation sheds light on the issue once and for all.
Help other customers find the most helpful reviews 


5 of 5 people found the following review helpful
5.0 out of 5 stars  June 10, 2010
By Nickyanne Laman "Nicky Laman" (Portland, OR) (REAL NAME)   
Amazon Verified Purchase(What's this?)

Who doesn't know someone who is suffering from MS or other Diseases of Civilization? 
This is essential information that can change the quality of a lot of lives.
Kudos to Dr. Monte. who has laid out a clear and engaging case for methanol being the Trojan Horse that is responsible for all this suffering.
And as a food scientist, he lays out a few simple dietary rules to follow that will make all the difference for so many people. 
It's nice to see someone who clearly cares so much, yet gives the facts with such a detailed reference system to back up his persuasive findings. 
His dedication is surely mission driven.
The truth about this stuff needs to get out to everyone. 
This could be the beginning of the end for MS & other Diseases of Civilization.

Nicky Laman, Founding Sales Director, Discovery Toys


3 of 3 people found the following review helpful
5.0 out of 5 stars He explains everything. Very detailed., June 16, 2012
By Aaron Holmgren 
Amazon Verified Purchase(What's this?)

He has very clear biological explanations, all referenced to research on the subject, and clearly explains why the methanol-multiple sclerosis hypothesis has been downplayed and overlooked by researchers from the time the disease was first discovered. 
This was a very insightful and convincing lecture on the methanol-multiple sclerosis hypothesis, to the point where I'm convinced it can be considered concluded.


3 of 3 people found the following review helpful
5.0 out of 5 stars A Physicians Perspective, May 17, 2010
By Ralph G. Walton (REAL NAME)   

This is a truly important video -- one which anyone who has MS, or cares about, or for, someone with this devastating illness must see. 
More broadly, anyone with an interest in what Dr. Monte calls "illnesses of civilization" -- Alzheimers, autism spectrum disorders, must watch and carefully consider this material. 
Dr. Monte's thesis is clearly presented, well reasoned and, in my opinion, absolutely correct


2 of 2 people found the following review helpful
5.0 out of 5 stars About time we got some straighr information, May 9, 2010
By Thomas E. Hollis (Albuquerque)  (REAL NAME)   

Just finished this and it is outstanding. Everyone in the developed world should read/see it.

I checked this Monte's credentials and he is everything he says he is. 
Also called some people to check him out and he's well known and respected in the field.

I couldn't believe how much information he gave and kept in such a logical framework that I followed it easily.
I did go back several times to make sure that he did say what I thought he said.
I'm just not used to hearing the truth so unvarnished.

It also is such a relief to find a bibliography at all, but this one is amazing.
I have looked up about a dozen and they do indeed say what he says they do.
Not always the case in technical writing with a point to make.

This is one of the few works I've seen in quite some time that backs up the epidemiological associations with good wet chemistry cellular pathways to verify the causes.


1 of 1 people found the following review helpful
5.0 out of 5 stars Monte's free online article Dec. 2007 gives full text references for his video talk, May 13, 2010
By Mr. Richard T. Murray "rmforall" (Santa Fe, NM USA) (REAL NAME)   

A medical layman, I've been active since 1999 as a conscientious volunteer information activist who provides online reviews of mainstream scientific research about aspartame (methanol, formaldehyde, formic acid) toxicity, as a public service.

Prof. Monte provides the best summary of the research.

His 145 minute DVD video presentation summarizes information explained in detail in a long article:
Monte WC. 2007, A Deadly Experiment.
Fitness Life. 2007 Dec.; 34: 38-42.

223 references with abstracts or full and partial texts


2 of 4 people found the following review helpful
5.0 out of 5 stars Why charge people., April 28, 2012
By LarryHonline 

If this is so life saving then why is it for sale on amazon?
He could have made a YouTube video for everyone at no cost to him or anyone else.
It would reach more people and save more lives.
I think the information is great.
I have progressive MS and agree that a good diet is important.

Comment (1)

Last edited by the author on Dec 30, 2012 9:30:53 AM PST

Free Thinking Voice says:

Larry, he did make a YouTube Video with Dr Mercola.

Radio Shows as well, with "The Earth Needs Rebels"

Google: YouTube Dr Monte Dr Mercola; or Monte "earth needs rebels"

He is great in live interviews as well.


Interview with Prof. Woodrow C. Monte, methanol formaldehyde toxicity
paradigm, 33 page plain text September 2012 Joseph M. Mercola DO: Rich
Murray 2012.11.11
http://rmforall.blogspot.com/2012/11/interview-with-prof-woodrow-c-monte.html

within the fellowship of service,
Rich Murray
http://rmforall.blogspot.com
Back to Top
Squiffy View Drop Down
Moderator Group
Moderator Group
Avatar
Moderator

Joined: 25 Jan 2013
Location: MS-UK
Status: Offline
Points: 767
Post Options Post Options   Thanks (0) Thanks(0)   Quote Squiffy Quote  Post ReplyReply Direct Link To This Post Posted: 08 Jul 2013 at 9:09am
Hi Rich, thank you for the additional articles.Big smile
"Don't think of me as being crazy. Think of me as abstaining from sanity..............."
Back to Top
RichMurray View Drop Down
Been here a while
Been here a while
Avatar

Joined: 03 Jul 2013
Location: United States
Status: Offline
Points: 17
Post Options Post Options   Thanks (0) Thanks(0)   Quote RichMurray Quote  Post ReplyReply Direct Link To This Post Posted: 08 Jul 2013 at 4:40pm
all symptoms are same from methanol, aspartame, MS -- Woodrow C. Monte paradigm, "While Science Sleeps" Rich Murray 2013.07.08

similar macular harm in multiple sclerosis as from formaldehyde made by ADH enzyme inside retina capillary walls from methanol, Prof. Woodrow C. Monte text "While Science Sleeps" 2012 Jan -- some quotes re retina harm: Rich Murray 2012.05.10
http://rmforall.blogspot.com/2012/05/similar-macular-harm-in-multiple.html
[ selection ]

WSS text, page 133 Chapter 9 Multiple Sclerosis (Kindle Locations 3809-3831)
free full text

"Symptoms Mean Little Unless They Are Identical in All Ways…Then They Mean Everything!

We have spent time on the symptoms of MS in Chapter 6, showing how methanol kills.
In summary, the symptoms of multiple sclerosis, 44, 83, 85, 169
chronic and acute methanol poisoning, 13, 144, 189
and Aspartame toxicity 54, 58, 93, 181
are in all ways identical.
Nothing that happens to the human body from the toxic effect of methanol that has not also been expressed during the course of MS -- nothing. 143, 144

This generalization extends even to the remarkable ophthalmological conditions common to both:
transitory optic neuritis and Retrolaminar demyelinating optic neuropathy with scotoma of the central visual field (which occasionally manifests as unilateral temporary
blindness). 85, 138, 163
In fact, these ophthalmological symptoms have been thought for years in their respective literatures to be “tell tale” indications for the differential diagnosis for each of these maladies independently. 85, 138, 148, 163, 169

The common symptoms of
headache, 13, 83, 181, 189
nervousness, 13, 83, 181
depression, 58, 83, 189, 181
memory loss, 18, 147, 85, 169, 181
tingling sensations, 13, 85, 168, 138, 169
pain in the extremities, 13, 85, 169
optic neuritis, 85, 138, 148, 163, 169
bright lights in the visual field, 139, 83
seizures, 21, 83, 160
and inability to urinate or to keep from urinating 139, 146, 167
are all shared by each of these conditions
and shared yet again by complaints from aspartame poisoning. 54, 58, 93, 181

I take these strikingly similar symptom patterns as evidence that these disorders act on identical components of the central nervous system and in the same way.

In the early stages of MS, or when a non-lethal dose of methanol has been administered, blindness can occur often in just one eye.
Complete recovery is a possibility.
The only two afflictions for which such dramatic “remissions” are reported from identical neuromuscular and ophthalmological damage, including “blindness,” are relapsing-remitting multiple sclerosis 85 and methyl alcohol poisoning. 138, 163

The pathology of the two maladies is in all ways identical,
particularly when it comes to destruction of the myelin sheath with no harm to the axon itself. 18, 148, 176

It is not unusual for the modern medical practitioner to put little credence in the similarity of symptoms between disorders, and it is indeed true that certain very common symptoms, such as headache and depression, can be caused by all manner of bodily changes.

However, the breadth of symptomatological overlap that we are putting forth here between methanol poisoning and MS is far too robust to put to neurological coincidence. In total, they reflect a link that cannot be refuted with any degree of scientific vigor."

"While Science Sleeps" text, pages 129-30 Chapter 9, Multiple Sclerosis,  (Kindle Locations 3712-3723)
http://www.whilesciencesleeps.com/multiple-sclerosis-the-solution/
free full text

[ Download a free copy of Chapter 9 and have a read
[ 99 pages, including list of all 745 full text online references for
book -- Chapter 9 has 146 references ]:

http://www.whilesciencesleeps.com/files/While%20Science%20Sleeps%20-%20Chapter%2\09%20(Prepublication%20copy)%20Website%203-15-2012.pdf

The references are located on his website:

http://www.whilesciencesleeps.com/references/ ,

as are the simple dietary changes that you must follow because your
life may depend on it:

http://www.whilesciencesleeps.com/monte-diet/ . ]


methanol/formaldehyde paradigm for multiple sclerosis, free full 56
page chapter 9 pdf, While Science Sleeps, 146 full text references
online, Prof. Woodrow C. Monte: Rich Murray 2012.03.20
http://rmforall.blogspot.com/2012/03/methanolformaldehyde-paradigm-for.html

within the fellowship of service,
Rich Murray
http://rmforall.blogspot.com
Back to Top
RichMurray View Drop Down
Been here a while
Been here a while
Avatar

Joined: 03 Jul 2013
Location: United States
Status: Offline
Points: 17
Post Options Post Options   Thanks (0) Thanks(0)   Quote RichMurray Quote  Post ReplyReply Direct Link To This Post Posted: 09 Jul 2013 at 5:36am
California OEHHA sets methanol ingestion level 23 mg daily, same as from 1 can aspartame diet soda, 10 cigarettes, 3 tomatoes, or 4 cans green beans: Rich Murray 2013.07.03
http://rmforall.blogspot.com/2013/07/california-oehha-sets-methanol.html


"However, the anticipated exposure to methanol from consumption of aspartame would not be considered an exposure within the meaning of Proposition 65 because aspartame is not listed under Proposition 65. "


[ Rich Murray: Many pregnant women drink one 12-oz can aspartame diet drink daily, with 200 mg aspartame that gives 11% methanol, 22 mg, which is just under the OEHHA limit of 23 mg daily.

The smoke from 10 cigarettes gives 20 mg methanol, the same as from  3 full size fresh tomatoes, or 4 cans of green beans. ]

See also:

James McDonald to EFSA, outdated aspartame ADI gives methanol 35 times too high for human safety, ten minute talk at April 9 public sharing, Brussels: Rich Murray 2013.04.15
http://rmforall.blogspot.com/2013/04/james-mcdonald-to-efsa-outdated.html


aspartame harm in rat brain from 75 mg/kg gives human ADI 0.75 mg/kg, 53
times less than EU ADI 40 mg/kg, Ashok Iyyaswamy, SheelaDevi Rathinasamy,
U. Madras 2012.08.03 free full text -- main methanol toxin is formaldehyde,
not formate: Rich Murray 2013.06.01
http://rmforall.blogspot.com/2013/06/aspartame-harm-in-rat-brain-from-75.html


more lower aspartame and methanol ADIs from studies by RH Nair, SheelaDevi
Rathinasamy, WC Monte, PS Jeganathan, A Namasivayam, Hazleton Labs, Searle
Labs: Rich Murray 2013.06.01
http://rmforall.blogspot.com/2013/06/more-lower-aspartame-and-methanol-adis.html


"In addition to the aforementioned comments received by OEHHA during the comment period, several emails were received from Mr. Rich Murray.

None of the emails from Mr. Murray stated an objection to or made any recommendation regarding the proposed action.

The emails contained website URLs and quotes from websites that discuss aspartame, an artificial sweetener.

Methanol is known to be a metabolite of aspartame.

Because Mr. Murray did not indicate how the information pertains to the methanol MADL, and did not otherwise comment on the methanol MADL, no formal response is being provided.

However, the anticipated exposure to methanol from consumption of aspartame would not be considered an exposure within the meaning of Proposition 65 because aspartame is not listed under Proposition 65.

Further, the level of exposure to methanol from aspartame metabolism among pregnant women that consume aspartame can be calculated to fall below the oral MADL using information from the National Toxicology Program’s report on methanol 3."

[ Rich Murray: Many pregnant women drink one 12-oz can aspartame diet drink daily, with 200 mg aspartame that gives 11% methanol, 22 mg, which is just under the OEHHA limit of 23 mg daily.

The smoke from 10 cigarettes gives 20 mg methanol, the same as from  3 full size fresh tomatoes, or 4 cans of green beans. ]
[ much more ... ]

within the fellowship of service,
Rich Murray
http://rmforall.blogspot.com
Back to Top
RichMurray View Drop Down
Been here a while
Been here a while
Avatar

Joined: 03 Jul 2013
Location: United States
Status: Offline
Points: 17
Post Options Post Options   Thanks (0) Thanks(0)   Quote RichMurray Quote  Post ReplyReply Direct Link To This Post Posted: 10 Jul 2013 at 6:13am
methanol/formaldehyde paradigm for multiple sclerosis, free full 56
page chapter 9 pdf, While Science Sleeps, 146 full text references
online, Prof. Woodrow C. Monte: Rich Murray 2012.03.20
http://rmforall.blogspot.com/2012/03/methanolformaldehyde-paradigm-for.html
http://health.groups.yahoo.com/group/aspartameNM/message/1642


http://www.whilesciencesleeps.com/multiple-sclerosis-the-solution/

Multiple Sclerosis: The Cause and the Solution Uncovered -- at Last!

An exhaustive analysis of the medical and scientific literature,
authored by a uniquely qualified food scientist, persuasively reveals
the cause of MS and describes a path to recovery and prevention.

The symptoms of Multiple Sclerosis are identical to those of an
uncommon form of poisoning -- methanol poisoning.
Individuals who have been exposed to this poison over a long period of
time, in fact, develop MS.
This poison -- methanol -- is a major component of cigarette smoke,
which, until now, has been the only known cause of Multiple Sclerosis.

Dr. Monte's compelling work reveals that this poison is also contained
in certain foods that are canned and smoked or have had the insidious
sweetener, aspartame, added to them.
Unfortunately, the truth has been obscured due to the fact that
methanol is a poison only to humans and not to (laboratory) animals.

If you have MS, or love someone who does, you and your physician
should read what Dr. Monte has to say about methanol and its link to
MS.
To expedite the free exchange of what might be lifesaving information
about this disease, there is a file attached below to his website that
contains a full copy of Chapter 9 of his book, While Science Sleeps.
This chapter examines the cause of MS and posits the simple dietary
changes that can save your life.

Download a free copy of Chapter 9 and have a read
[ 99 pages, including list of all 740 full text online references for
book -- Chapter 9 has 146 references ]:

http://www.whilesciencesleeps.com/files/While%20Science%20Sleeps%20-%20Chapter%2\
09%20(Prepublication%20copy)%20Website%203-15-2012.pdf

The references are located on his website:

http://www.whilesciencesleeps.com/references/ ,

as are the simple dietary changes that you must follow because your
life may depend on it:

http://www.whilesciencesleeps.com/monte-diet/ .

Everything you need to know about MS is in Chapter 9.
If you are interested in knowing more about methanol poisoning and its
link to other diseases of civilization, you will want to read the
entire book, While Science Sleeps, by Woodrow C. Monte PHD, Emeritus
Professor of Nutrition and Food Science, Arizona State University.

Chapter 9:
Multiple Sclerosis

The Conflagration that is Multiple Sclerosis;
Listening to Nature’s Whispers;
The Scene of the Crime;
Location, Location, Location;
Details of Plaque Formation;
The Look, Touch, Taste and Smell of Multiple Sclerosis;
The Kitchen Autopsy;
The Cause of MS is within the Thickening Blood Vessels;
Symptoms Mean Little Unless They Are Identical in All Ways…Then They
Mean Everything!;
Learn a Little About Arginine;
Myelin Basic Protein (MBP);
Looking for the Shadow of Formaldehyde;
“Woody… They Have Done Our Experiment for Us.… But They Just Don’t Get It!”;
Finding the Shadow of Formaldehyde in the MS Brain: The Smoking Gun (a
Triple Blind Study);
Evidence That Methanol Causes MS;
The Etiology of Multiple Sclerosis -- Follow the Methanol;
A Food Scientist’s Nightmare Called Aspartame;
MS: a Disease of Colder Climates and Flush Toilets -- Before Aspartame;
A World Awash in MS after Aspartame;
Change in Frequency of MS by Sex:
the Methanol Source -- Food or Smoke -- Makes All the Difference;
Can Methanol Really Cause MS?;
MS Can Be Found in Some Places, but Cannot be Found in Others;
Industrial Exposure to Methanol -- Jobs that Can Last for an Eternity;
Teachers’ Paradigm;
MS Treatment -- Pharmaceutical Placeboes or Perhaps Worse;
Conclusion and Review;

Conclusion and Review

You can see for yourself now that the daily administration of methanol
to the human organism does not go unnoticed by the immune system.
The evidence is simply far too overwhelming for the pharmaceutical
industries to credibly justify ignoring it any longer.
As a scientist I can do little more than present a coherent molecular
theory, and then prove the hypothesis using three paradigms with two
distinct methods of methanol administration.
Viewing methanol toxicity as the etiologic cause of MS answers all of
the nagging questions and unexplained anomalies that have stalled the
search for the cause of this disease.
I realize that absolutely nothing can convince the pharmaceutical
giants, who are now heavily invested in developing their own useless
palliatives for MS, to give them up and rally around the methanol
hypothesis.
In the end, however, I believe that the truth will win out.
Henry Miller prophesied over 50 years ago:
It is possible that the cause of multiple sclerosis lies buried
somewhere in these lengthy protocols waiting to be found by someone
ingenious enough to unearth it.[#306]

Review

1. MS is a disease that begins around brain blood vessels, adjacent to
the exact locations where methanol converts to formaldehyde, very much
like Alzheimer’s Disease.

2. MS was first discovered long before formaldehyde, making the
determination of its cause impossible.

3. The vast majority of early researchers believed that the cause of
MS was a “toxic substance” that forms in and is distributed via the
blood vessels of the brain. “Whatever is being produced within the
vessel walls is the cause of the disease.”

4. All symptoms of MS can be found during the course of methanol
poisoning if the patient lives long enough.

5. Myelin Basic Protein (MBP) is the protein of the myelin sheath that
is removed during MS plaque development.
MBP contains a high percentage of arginine, which acts as a trap for
formaldehyde.
The MBP of MS patients has been shown to have reacted with
formaldehyde and cause a marked increase of the methylation of its
arginine.

6. The MBP of MS brain tissue has been shown to be severely deficient
in phosphorylation, which we know can be caused by formaldehyde.

7. The Smoking Paradigm: Cigarette smoke is high in methanol and is
the only etiological cause of MS that is generally accepted by the
scientific community.

8. Consistent circumstantial evidence links increases in
methanol-containing food consumption and in industrial use of methanol
to corresponding increases in MS incidence during the transition from
the 19th century into the 20th century.

9. The advent of aspartame, a methanol carrier, has introduced an
opportunity to quantify additional methanol in the food supply since
1981.

10. The Aspartame Paradigm: statistics show convincingly that as more
and more aspartame is consumed by the US population the incidence of
-- and perhaps more importantly the death rate from -- MS has also
increased dramatically.

11. The higher incidence of MS in colder climates was due to the
higher consumption levels of canned fruits and vegetables in temperate
climates.
This began reversing shortly after methanol-containing diet sodas and
other thirst quenching products became popular and inexpensive in the
tropics.

12. MS was at one time a disease of men when it was caused by
industrial contact.
It is increasingly more of a women’s disease.
When methanol is inhaled as a gas during cigarette smoking or
industrial contamination the distribution tends to be equal between
the sexes.
The stomach of the man, however, has 4 or 5 times more ADH in its
lining than that of a woman.
When methanol is consumed via diet soda, the ADH removes methanol
before it can get to the brain, so less of it reaches men’s brains
than women’s brains.
As more and more methanol has become a dietary poison, the shift from
male to female disease has followed.

13. The Faroe Islands are surrounded by countries with very high
incidence of MS, yet the country traditionally did not have the
disease represented in its population until after the occupation of
large numbers of British Troops during the Second World War.
Faroes have no trees or peat deposits and, therefore, developed
methods to salt and air dry fish and other meats for preservation,
unlike its neighbors, who dine on smoked foods at each meal.
The indigenous diet of the Faroans contains no methanol.

14. The Village of Wellington, Ohio experienced an epidemic of MS that
should have been traced to the escape of methanol fumes from a
foundry, affecting the populace located downwind of it.

15. Professions such as shoe making and papermaking that have been
shown to have high incidence of MS can also be shown to have exposed
their workers to levels of methanol.

16. The Teaching Paradigm:
The US teaching profession might just be the best profession to use to
link methanol exposure to increased incidence of MS.
Secondary school teachers suffer an incidence of MS almost twice as
high as their professional counterparts.
They also can be shown to have had consistent workday exposure to
methanol fumes by the ubiquitous use of Ditto machines that use high
concentrations of methanol as a print transfer agent.

It has been over 30 years since I heard my first unsolicited plea for
help from an aspartame consumer who had linked consumption of the
product to her suffering. My first thought after an hour’s listening
was that this courageous young woman would soon be diagnosed with
Multiple Sclerosis.
It is in her honor and in the memory of my friend from Wellington,
Colorado that I seek to explain the compelling link between methanol
and MS.


[ http://www.whilesciencesleeps.com/pdf/224.pdf

224. Kim J, Mastronardi F, Wood D, Lubman D, Zand R, Moscarello M.
Multiple Sclerosis: An important role for post-translational
modifications of myelin basic protein in pathogenesis.
Molecular & Cellular Proteomics 2003;2(7):453-62.

http://www.ncbi.nlm.nih.gov/pubmed/12832457 abstract

http://www.mcponline.org/content/2/7/453.full?sid=4999b20c-f767-4934-88e4-7a8cc4\
1ee4ca
free html rich full text version ]


The Monte methanol paradigm posits a simple, obvious major co-factor
for many novel diseases of civilization -- vastly increasing the
opportunity for extremely positive social service via avoiding all
methanol sources: Rich Murray 2012.02.06

Methanol from smoking and aspartame, in humans alone, is always made
into formaldehyde via the ADH enzyme inside the cells of blood vessels
and many tissues -- a little alcohol protects.

Many novel diseases of civilization result since 1800 -- heart,
stroke, Alzheimers, cancers, MS, autism, spina bifida -- increasing
rapidly with aspartame since 1981.


4 more positive reviews for While Science Sleeps, Prof. Woodrow C.
Monte, on Amazon.com: Rich Murray 2012.02.26
http://rmforall.blogspot.com/2012/02/4-more-positive-reviews-for-while.html
http://health.groups.yahoo.com/group/aspartameNM/message/1641


While Science Sleeps, methanol from cigarettes and aspartame becomes
formaldehyde inside human cells -- Table of Contents, WC Monte bio,
Kindle electronic book version $ 9.80 Amazon.com: Rich Murray
2012.01.26
http://rmforall.blogspot.com/2012/01/while-science-sleeps-methanol-from.html
http://health.groups.yahoo.com/group/aspartameNM/message/1636


new book, concise opus "While Science Sleeps" life saving facts re
aspartame (methanol, formaldehyde) -- 740 full text references are
free online -- Woodrow "Woody" C. Monte, retired Prof. of Nutrition,
Arizona State University: Rich Murray 2012.01.03
http://rmforall.blogspot.com/2012/01/new-book-concise-opus-while-science.html
http://health.groups.yahoo.com/group/aspartameNM/message/1631

www.WhileScienceSleeps.com

$ 37.98 text 236 pages -- 745 full text references free online --
Kindle electronic book, $ 9.80

http://www.amazon.com/review/RNGG3O7U33VCV


Rich Murray,
MA Boston University Graduate School 1967 psychology,
BS MIT 1964 history and physics,
254-A Donax Avenue, Imperial Beach, CA 91932-1918
rmforall@gmail.com
505-819-7388 cell
619-623-3468 home
http://RMForAll.blogspot.com

Back to Top
RichMurray View Drop Down
Been here a while
Been here a while
Avatar

Joined: 03 Jul 2013
Location: United States
Status: Offline
Points: 17
Post Options Post Options   Thanks (0) Thanks(0)   Quote RichMurray Quote  Post ReplyReply Direct Link To This Post Posted: 10 Jul 2013 at 11:23pm
skeptic Josh DeWald often sides with industry PR while finding flaws in many common anti aspartame claims in video "Sweet Misery", Cori Brackett: Rich Murray 2013.07.10

http://rmforall.blogspot.com/2013/07/skeptic-josh-dewald-often-sides-with.html



I support vigorous  civil debate by all points of view, based on reason and public evidence, so I am making many discussions more available here.



http://www.soundandfury.tv/  Cori Brackett


1 hour 34 minutes


interview 2013.01.28

My guest for this interview is Cori Brackett, creator of the powerful and thought-provoking documentaries Sweet Misery and Sweet Remedy.

Cori talks about her own experience of being diagnosed with multiple sclerosis and describes how, through her research, she came to believe that the artificial sweetener aspartame played a significant role in her illness. ]



MercolaWatch: The Sweet Misery documentary

7.5.2013 | by Josh DeWald

I have intentionally been trying to avoid posting about aspartame, but Joe Mercola recently posted a reference to the relatively old Sweet Misery anti-aspartame documentary which I have already seen more times that I would like and responded to. This documentary features interviews with the main players in the anti-aspartame movement, who make statements that simply are not supported by the evidence. On my other blog, I have a 2-part “fact check” (Part 1Part 2) of the documentary.

Sweet Misery Fact Check – Part 1

Posted on July 8, 2011 by Josh DeWald

There is an HTML version available at  http://tinyurl.com/sweetfact1

A PDF version is available at:


Sweet Misery Fact Check – Part 2

Posted on August 3, 2012 by Josh DeWald 



Aspartame and Formaldehyde (or not…)

Posted on June 13, 2010 by Josh DeWald

long detailed critique with vigorous debate by 162 Responses

A possibly easier to read version of this better for pinting is available at  http://40two.org/Aspartame_Formaldehyde.pdf

There is also a separate entry which is a response to a Joe Mercola article posted to the Huffington Post which repeated some of the claims refuted here, as well as some additional ones. ]


If you have seen the documentary and read the article I urge you to take a look at my existing responses, but here I will offer a quick rundown of some of the key claims and responess.

Sweet Misery includes many heartfelt conversations with aspartame victims….”

This line about summarizes the bulk of the documentary: anecdotes. It features virtually nothing in the way of science, but is filled with stories from people that believe that they have been harmed by aspartame or from “experts” that can explain why someone would be harmed from aspartame. But it generally amounts to conspiracy theories or hypotheses that have already been studied and rejected by the scientific community.

Multiple Sclerosis

While Mercola only briefly mentions it, the documentary spends a lot of time discussing the alleged link between aspartame and multiple sclerosis (as well as some other disorders for which scientists honestly do not know exactly what causes it or how to cure it, such as fibromalgia).

This is in my Part 1, but there is simply no evidence that would link MS with aspartame. The only mention of aspartame on the National Multiple Sclerosis Society’s is on their page “Old Theories That Have Been Disproved“. Suffice to say they do not support the association and do not advise their members against aspartame. The Multiple Sclerosis Foundation also has a page “Examining the Safety of Aspartame” where they essentially call it out as all starting with an internet hoax post from “Nancy Merkle” and note that “aspartame appears to be quite safe” (aside from possible mild side effects in some people).

As to the multiple claims in the documentary, and Internet-at-large, saying that when they stopped consuming aspartame their symptoms went away, it turns out that the most common form of MS, known as Relapsing-Remitting, is actually known to go into spontaneous remission for months, years, or even completely

Brain Tumors

The documentary spends some time discussing the famous study by JW Olney to the effect that there was a dramatic rise in brain tumors following the introduction of aspartame into general use. The National Cancer Institute and French Food Safety Authority both slammed the study. The National Cancer Institute notes that had Olney included more years from before the introduction of aspartame, the graphs would have clearly shown brain cancers rising “8 years prior” to the introduction of aspartame, and this mainly in older people 70 or older. The French authority echoes that, adding that brain cancers actually stabilised in the mid-80s when aspartame came out.

So deeper looks at the data just don’t support the link between aspartame and brain cancer.

Blood Cancer (Lymphoma)

I don’t recall it from the documentary, but Mercola mentions the recent lymphoma study which he says finds a “clear association” between aspartame and lymphoma. I wrote about this study when he originally cited it. I will simply requote the study author’s own conclusions:

Although our findings preserve the possibility of a detrimental effect of a constituent of diet soda, such as aspartame, on select cancers, the inconsistent sex effects and occurrence of an apparent cancer risk in individuals who consume regular soda do not permit the ruling out of chance as an explanation.

Brigham and Women’s Hospital, who’s PR department promoted the study actually essentially apologizedbefore it was even published:

It has come to our attention that the scientific leaders at Brigham and Women’s Hospital did not have an opportunity, prior to today, to review the findings of the paper,[...] Upon review of the findings, the consensus of our scientific leaders is that the data is weak, and that BWH Media Relations was premature in the promotion of this work. We apologize for the time you have invested in this story

“Clear association”? Hardly. But Mercola and others will likely continue to cite it as strong evidence, without any sort of caveat.

Methanol Toxicity

In Mercola’s notes, he discusses the claim that humans are incapable of properly processing methanol and, therefore, aspartame is dangerous. Amazingly, Mercola does not even do the typical anti-aspartame play that all the other foods that have methanol as a breakdown product (such as fruits, vegetables, wine) are “special”.

Methanol (methyl alcohol) is of course dangerous when taken in large acute doses. There does not appear to be any build-up whatsoever of formic acid in the body (Stegink 1978) (it is excreted in urine) for normal consumption of aspartame. Only someone with the inability to process the formic acid/formate out of their system would be reasonably expected to have issues with aspartame and products that breakdown into methanol. I discuss this in the “Part 1″ linked above as well as in another article (which was actually my first on aspartame, and now has quite a few comments on it of anti- and pro-aspartame folks battling it out which turns out to be quite interesting).

Thousands of complaints, 90+ symptoms

Another of the standard tactics of the anti-aspartame folks is to state that there are “more than 10,000 complaints” involving 90+ symptoms (usually it’s cited as 92, but Mercola says 91). As readers of this blog are probably now aware, filing a report with the Adverse Event Reporting System (AERS, with vaccine equivalent VAERS) is not even remotely equivalent to being evidence or proof of harm. They are merely data points. You can download them in fact (good luck finding aspartame listed, or on the “potential hazards” list), and have no use until properly analyzed and investigated. A 1992 investigation (making use of the actual patient data and their consumption patterns as well as direct “challenge tests”) into the seizure-related AERS data found no association with aspartame.

Walton’s list of “independent” studies against aspartame

I chuckle a little bit every time this list gets mentioned. The film has Walton himself mentioning it. If what he had found was in fact 97 studies against aspartame, that would be something. But he did not. Not even close. I classified the entries on a Google Spreadsheet and discussed in “Part 2″ of my look at the documentary before as well as in a prior article on aspartame and formaldehyde . At best, five — 2 on seizures, 1 on headaches, 1 a famous debunk’d study, and another was not able to be reproduced — of them could be considered both peer-reviewed and relevant to aspartame. The rest are about methanol generically, find no harm (not sure why he includes these) or are just letters to the editor and case studies. I urge anybody who takes the documentary at face value on this point to look at the full list to see if it really represents evidence against aspartame.

Shenanigans during approval process

  • “Covered up” Waisman monkey study – Waisman actually died before the study was completed , but Searle still submitted the data they had to the FDA (so certainly not “covered up”). Seizures occurred in the medium and high dose groups (100 and 120x maximum daily intake). However, same can be induced using equivalent amounts of phenylalanine (one of the components of aspartame).
  • FDA commissioner “illegally” overruled Board of Inquiry decision – Not illegal, the Board of Inquiry is not a legal body (Code of Federal Regulations Title 21, Subpart B, S. 13.30). The commissioner felt that there had been ample demonstration of safety. Additional details can be read in the Government Accounting Office’s 1987 report on the approval process of aspartame.
  • “Clear conflict of interest” when Searle paid for independent analysis – FDA required them to pay for the study by UAREP. It was in no way sponsored by Searle.
  • Reagan’s first executive order removed FDA’s ability to prevent marketing of aspartame – This never happened (Federal Register).

Conclusion

As popular as it is, Sweet Misery is not an accurate portrayal of the scientific evidence regarding aspartame. It is full of anecdotes that do not stand up to scrutiny. It presents a series of conspiracy theories about the approval process, but offers no substantiation. I would recommend only watching the movie if you want to see what a long string of anecdotal evidence looks like (sincerely believed though they may be, I have no doubt about the honesty of the people portrayed in the film). The main part of the film I have not covered is the claim that Diane Fleming was wrongly convicted of murdering her husband via methanol poisoning (the documentary, not surprisingly, alleges that he was killed from aspartame in has gatorade and diet drinks).

Tagged in aspartame / mercola

About Josh DeWald  ,

I am a software engineer, husband and parent of two. I have been involved in the Skeptical movement for a few years now, especially since having children and so needing to fight pseudoscience related to parenting (vaccines, homeopathy, etc). I've been fortunate to attend TAM twice with my wife (who is also of a Skeptical bent). I also have a blog known as "What Does the Science Say?" ( whatdoesthesciencesay.wordpress.com ), where I have an odd habit of writing a lot about aspartame.





Skeptoid is hosted
and produced by
Brian Dunning

The Truth About Aspartame 2008.11.11


Contacting Skeptoid

Many people wish to contact Skeptoid, for such glamorous purposes as:

  • Throwing bricks
  • Shouting oaths & epithets
  • Exorcism

You've come to the right place. Select what you want to contact me about and I'll show you the best way:

  • Great, let's discuss it! Post your comments to the Skeptalk email discussion list ; or post them to the Skeptoid forum ; or if you prefer to just make your statement, use the comment form on the online transcript page for that particular episode (use the episode guide to find it).
     
  • I welcome your thoughts, but regret that I don't have time to engage in personal discussion with individual listeners. If you send feedback to me that could also be discussed in one of the appropriate forums, I'm probably just going to delete it.

About Skeptoid®

Skeptoid: Critical Analysis of Pop Phenomena is an award-winning weekly science podcast. Since 2006, Skeptoid has been fighting the good fight against the overwhelming majority of noise in the media supporting useless alternative medicine systems, psychics preying upon the vulnerable, the erosion of science education in the classroom, xenophobia of advanced energy and food production methods, and generally anything that distracts attention and public funding from scientific advancement.

Recent Download Statistics

Week of Jun 30 - Jul 6, 2013

176,100

Week of Jun 23 - Jun 29, 2013

168,081

Week of Jun 16 - Jun 22, 2013

248,903

Week of Jun 9 - Jun 15, 2013

173,742

Week of Jun 2 - Jun 8, 2013

165,310

Week of May 26 - Jun 1, 2013

212,083

Weekly Average

191,000



within the fellowship of service,
Rich Murray
http://rmforall.blogspot.com
Back to Top
RichMurray View Drop Down
Been here a while
Been here a while
Avatar

Joined: 03 Jul 2013
Location: United States
Status: Offline
Points: 17
Post Options Post Options   Thanks (0) Thanks(0)   Quote RichMurray Quote  Post ReplyReply Direct Link To This Post Posted: 10 Jul 2013 at 11:34pm
highly competent, pithy analysis of aspartame cancer study by Eva S.
Schernhammer at Harvard, William R. Ware, PhD, showing relevance of
Woodrow C. Monte methanol-formaldehyde toxicity paradigm: Rich Murray
2012.12.03
http://rmforall.blogspot.com/2012/12/highly-competent-pithy-analysis-of.html


Ethan Evers gives crisp summary of landmark study linking leukemia and
lymphoma in over 100,000 people using just 1.5 cans aspartame diet
soda daily for 22 years, Eva A. Schernhammer, Harvard expert team:
Rich Murray 2012.11.01
http://rmforall.blogspot.com/2012/11/ethan-evers-gives-crisp-summary-of.html


Eva A. Schernhammer cites Woodrow C. Monte methanol-formaldehyde
paradigm in brave, cautious Harvard team study that confirms more
cancers in aspartame diet soda users over 22 years -- full plain text:
Rich Murray 2012.10.27
http://rmforall.blogspot.com/2012/10/eva-schernhammer-cites-woodrow-c-monte.html


artificial sweeteners (aspartame): suggestive correlations with
multiple myeloma, non-Hodgkin lymphomas, leukemia in huge 22 year
Nurses' Health Study, Harvard, AJCN: Rich Murray 2012.10.24
http://rmforall.blogspot.com/2012/10/artificial-sweeteners-aspartame.html


California OEHHA sets methanol ingestion level 23 mg daily, same as from 1 can aspartame diet soda, 10 cigarettes, 3 tomatoes, or 4 cans green beans: Rich Murray 2013.07.03
http://rmforall.blogspot.com/2013/07/california-oehha-sets-methanol.html


fine critique by Josh DeWald of aspartame kidney harm survey, J Lin, GC Curhan 2011 -- now labs directly prove formaldehyde harm inside cells from blood methanol via ADH1 enzyme -- confirming methanol harm in alcoholics, lab study, E  Majchrowicz 1971 -- WC Monte paradigm: Rich Murray 2013.02.02
http://rmforall.blogspot.com/2013/02/fine-critique-by-josh-dewald-of.html

Josh DeWald, congratulations and thanks for an excellent, lucid, reasonable critique on this widely discussed study -- I will copy it to my blog  rmforall@blogspot.com .

Epidemiological studies seem to me to be mostly a waste of time, especially for methanol-formaldehyde toxicity disorders in humans:

1. ADH1 enzyme, which makes methanol into free floating formaldehyde right inside human cells, is itself free floating inside the cells of 19 specific tissues, especially the inner layers of blood vessels, the rods and cones of the retina, and in fibroblasts in skin and bone marrow -- thus there are as many different disorders, varying with the amount and pace of methanol ingestion, and a host of genetic, dietary, infectious, and toxic co-factors.

2. Folic acid in the blood offers some protection for some people, while many drugs and antibiotics impede folic acid function -- notably aspirin.

3. Ethanol, ordinary drinking alcohol, is a strong antidote for low levels in the blood, about an hourly oral dose of 3 ml 80 proof vodka, which in many people is provided by fermentation by bacteria in the GI tract (so the toxic "side effects" of antibiotics and many drugs may to some unknown degree be via disruption of this ethanol production, leading to formaldehyde toxicity within the cells of vulnerable tissues) -- other ethanol sources include most fruits and many vegetables, which strongly reduce the harm from their high levels of methanol.

Also, this explains the mystery that those who never drink have about twice the level of symptoms from many modern novel chronic diseases as those who drink about one shot (3 ounces volume) of 80 proof vodka daily, while larger daily doses lead to increased harm -- called the U-shaped curve -- which may be a major clue that chronic methanol-formaldehyde toxicity is involved.

Daily heavy drinkers end up with high blood methanol levels, as the ethanol stops the main process of methanol metabolism, so when in a lab experiment the high level of intake was stopped suddenly after two weeks, the resulting high blood methanol levels, with a half-life of 3 hours, dropping 16 fold in 12 hours, generated dangerous alcohol withdrawal symptoms that only started when blood ethanol, with a half life of 20 minutes, dropped 36 fold to effectively zero 16 hours after cessation, allowing the ADH1 enzyme to start making the methanol into formaldehyde within cells.

http://www.whilesciencesleeps.com/references/  745 free full texts

http://www.whilesciencesleeps.com/pdf/133.pdf
133.  Majchrowicz E. Biochemical Pharmacology of Ethanol.
New York: Plenum Press; 1973.

http://www.whilesciencesleeps.com/pdf/134.pdf
134. Majchrowicz E, Mendelson J.
Blood Methanol Concentrations During Experimentally Induced Ethanol Intoxication in Alcoholics.
The Journal of Pharmacology and Experimental Therapeutics 1971;179:293-300.

4. Few indeed know that the smoke from a pack of cigarettes gives as much methanol as a liter of aspartame diet soda -- so most of the long-term chronic symptoms of cigarette use may actually be evidence for methanol-formaldehyde toxicity: Alzheimer's, multiple sclerosis, atherosclerosis, and birth defects spina bifida, autism, preterm birth, many cancers, etc.

Methanol (wood alcohol) comes from wood smoke as well, while peat smoke gives three times higher doses -- hence highest world incidence of multiple sclerosis is in Scotland, where smoked fish is a daily staple.

5. So, modern methanol sources include:
aspartame,
smoke from cigarettes wood peat,
dark wines and liquors,
fresh tomatoes,
unfresh fruits juices vegetables cut up and preserved wet at room temperature in sealed cans jars plastic containers,
smoked, fermented, spoiled foods,
jams jellies marmalades,
mortuary medical chemical industrial facilities, especially wood and paper factories.

6. New precision methods now make it possible to directly confirm toxic formaldehyde products in tissues from methanol:

apoE4 protein scaffold allows growth of human neurons in lab,
Kwang-Min Kim et al, Brown U -- can test harm from formaldehyde made
from methanol by ADH1 enzyme inside cells of inner walls of brain
blood vessels, WC Monte paradigm: Rich Murray 2013.01.29
http://rmforall.blogspot.com/2013/01/apoe4-protein-scaffold-allows-growth-of.html


Initial tests could use micro gram amounts of formaldehyde to show the
typical processes of harm within neurons:

confirms WC Monte paradigm: ingested methanol becomes toxic
formaldehyde-induced hydroxymethyl DNA adducts in all tissues in rats,
sensitive C13 test, Kun Lu, James A Swenberg, UNC Chapel Hill
2011.12.08 Toxicol Sci: Rich Murray 2013.01.11
http://rmforall.blogspot.com/2013/01/confirms-wc-monte-paradigm-ingested.html

Then, if neurons can be grown along with small brain blood vessels,
with ADH1 enzyme free floating within the cells of the inner layers of
the vessels, the effects of formation of formaldehyde in situ from
micro grams of added methanol can be studied, confirming the WC Monte
paradigm, described in detail at www.WhileScienceSleeps.com and backed
by a free online archive of 745 full text medical research references.


Blood methanol concentrations during experimentally induced ethanol intoxication in alcoholics.
Edward Majchrowicz, Jack H. Mendelson.
J. Pharmacol. Exp. Ther. 179: 293-300, 1971.

[ comments by Rich Murray are in square brackets. ]

Abstract

Accumulation of methanol in blood was detected in alcoholic subjects during a 10- to 15-day period of chronic alcohol intake.

Blood methanol levels increased progressively from 2 to 27 mg/l from the 1st to 11th day of drinking, when blood ethanol concentrations ranged between 1500 and 4500 mg/l.

Blood ethanol was eliminated at the rate of 2720 +- 30 mg/l/hr within 14 to 18 hours after cessation of drinking.

Blood methanol levels decreased at the rate of 2.9 +- 0.4 mg/l/hr only after blood ethanol levels decreased to 700 to 200 mg/l.

Blood methanol disappearance lagged behind the linear disappearance of ethanol by approximately six to eight hours, and complete clearance of blood methanol required several days.

The pattern of accumulation and clearance of methanol and ethanol was similar for subjects who consumed either beverage alcohol (bourbon) or methanol-free grain alcohol.

Methanol probably accumulates in the blood as a result of competitive inhibition of alcohol dehydrogenese by ethanol, and the presence of endogenously formed methanol or its metabolites may contribute to the severity of intoxication and/or the alcohol withdrawal syndrome.

[ paper first presented at an April 1970 meeting ]

[ Probably these alcoholics smoked a lot in 1969 --

cigarettes were unrestricted in a small urban psychiatric hospital I worked in as a night therapist in 1988 in Santa Fe, New Mexico.

Few know that the smoke from a pack of cigarettes gives 60 mg methanol, 3 mg per cigarette...

Cigarettes correlate with many modern novel chronic diseases, including Alzheimer's and multiple sclerosis, atherosclerosis, many cancers, and birth defects spina bifida, autism, preterm birth, and fetal alcohol syndrome.

Methanol is actually less toxic than ethanol, unless it meets up with any ADH1 enzyme inside cells without any ethanol present, which quickly turns methanol into toxic formaldehyde inside the cells of 19 specific human tissues, including liver, brain, retina, skin, fetus.

During high daily use of ethanol, the ADH1 enzyme is preoccupied, so it cannot turn blood methanol from any source into formaldehyde, so blood methanol levels rise and rise, not causing any symptoms -- this probably caused much of the increase in blood methanol with large ethanol intake for two weeks.

Without any ethanol, the blood half-life of ethanol is still just 1/3 hour, while the blood half-life of methanol is 3 hours, so every 9 hours, the ethanol falls 27 times, while methanol blood levels would fall 8 fold, but if the men increase their smoking, the methanol levels decline only a little, as happened to many male alcoholics in this study.  After about 16 hours, the ethanol is zero, and then the remaining methanol is quickly made into highly toxic formaldehyde right inside cells by the ADH1 enzyme.  If then the patient is too sick to eat or smoke, he will not be taking in any more methanol, which will drop to 1 mg/l, sometimes a few days later.

Methanol also comes from the pectins in unfresh fruits juices vegetables cut up and preserved wet at room temperature in cans jars plastic containers -- i.e. classic institutional diet.. ]


[ 19 male alcoholics were given 32 ounces by volume of 50% ethanol drink for 10 - 14 days in a closed hospital ward -- blood methanol was measured with 1.0 mg/l accuracy -- 

...All samples from the subjects before the commencement of drinking and three to four days after the cessation of drinking, and from control subjects, had negligible amounts of methanol, whereas the subjects had variable amounts of methanol during the experimental drinking period....

...During the predrinking period, blood methanol levels were always less than 1.0 mg/l. [ 1 ppm ]

On the first day of drinking, blood methanol concentrations were between 1 and 2 mg/l when the mean range of blood ethanol concentrations ranged between 55 and 3540 mg/l.

As drinking continued, mean blood methanol levels ranged between 11 and 27 mg/l when the mean blood ethanol concentrations were between 1570 and 4350 mg/l.

On a few occasions, blood methanol concentrations of 40 mg/l or more were detected in subjects whose blood ethanol concentrations exceeded 5000 mg/l.

[ These methanol blood levels of 11, 27, and 40 or more ppm are the levels that, made by ADH1 enzyme into formaldehyde inside cells in 19 specific human tissues, especially brain blood vessels and the retina rods and cones, may well be the main trigger for the gamut of painful symptoms of alcohol hangover, "the morning after the night before". ]

Although blood ethanol levels fluctuated daily, they were  usually high enough to induce and maintain a significant degree of clinical intoxication.

Blood methanol and blood ethanol concentrations after cessation of drinking are shown in Figure 2.

Blood ethanol values ranged between 2000- and 4000 mg/l at the initiation of the withdrawal period.

Usually, ethanol was not detected in the blood after 14 to 18 hours following cessation of drinking.

However, in a few subjects traces of ethanol approximating 10 mg/l were detected up to 20 hours after ethanol withdrawal.

The concentration of blood methanol remained relatively constant in both groups of subjects until blood ethanol levels decreased to approximately 200 mg/l.

At this blood ethanol level blood methanol concentrations began to decline and, in most instances, blood methanol was cleared within two days after cessation of drinking.

However, in a few cases disappearance of accumulated methanol did not occur until three or four days after termination of drinking.

Figures 3 and 4 present typical blood methanoI and blood ethanol curves as a function of time during drinking and withdrawal for subjects who consumed either bourbon or grain alcohol.

[ Figure 3 shows the data for a bourbon drinker, whose ethanol peaked at  3400 mg/l , and methanol at 24 mg/l, while only after 11 hours after cessation, when ethanol was down to 200 mg/l   and methanol 19 mg/l, until 3 hours later, 14 hours after cessation, with ethanol reaching zero, and methanol falling to 7 mg/l, do we see the abrupt conversion of most of the methanol into formaldehyde, reaching the last measured methanol value of about 1 by about 5 more hours, about 19 hours after cessation -- the authors are not gifted at making clear graphs.

Figure 4 shows the data for a grain alcohol drinkers, whose ethanol peaked at 4500 mg/l, and methanol at 15 mg/l, while only after 16 hours after cessation did ethanol levels fall to zero, with methanol levels then falling steeply from 15 to 1 mg/l 8 hours later, 24 hours after cessation.

We can only speculate how much less they may have eaten and smoked during two weeks of intoxication, and a severe alcohol withdrawal syndrome for a day or two -- hospital food and cigarettes would prolong the methanol-formaldehyde toxic syndrome. ]

Blood methanol levels increased progressively from 2 mg/l on the first day of drinking to 23 mg/l in the bourbon subjects by the 11th day of drinking.

A similar pattern of ascending blood methanol levels is related to the duration of ethanol ingestion.

The concomitant pattern of increase in blood methanol levels was highly consistent and was categorized into four phases.

Low methanol concentrations were found during the first day of drinking (phase I), but as drinking continued, methanol levels progressively increased (phase II).

The highest levels of blood methanol were found at the termination of the drinking period.

After alcohol withdrawal, blood methanol levels remained relatively stable for about 15 to 18 hours (phase III), but when blood ethanol levels decreased to approximately 700 to 200 mg/l, methanol levels began to decline (phase 1V).

Thus, blood  methanol disappearance lagged behind the linear disappearance of ethanol by approximately six to eight hours, and complete clearance of blood methanol accumulation and elimination in grain alcohol drinkers was similar to that of bourbon drinkers.

...methanol content varied between 40 and 55 mg/I of bourbon.

This value is comparable with those reported by the distillers.

The concentration of methanol in 50% grain alcohol was approximately 1 mg/l.

Average daily consumption of bourbon or grain alcohol was 649 and 781 ml/subject; respectively.

Assuming the mean concentration of methanol in the bourbon is 48 mg/I the daily ingestion of methanol was 31 mg/man.

After absorption and equilibration, this dose of methanol would result in a concentration of 6 mg/kg of body water in a 70-kg man.

[ So, 60 mg methanol from smoke from a pack of cigarettes would lead to twice as much, 12 mg/kg of body water in a 70-kg man. ]

[ Probably these alcoholics smoked a lot in 1969 -- cigarettes were unrestricted in a small urban psychiatric hospital I worked in as a night therapist in 1988 in Santa Fe, New Mexico.  Few know that the smoke from a pack of cigarettes gives 60 mg methanol, 3 mg per cigarette... Cigarettes correlate with many modern novel chronic diseases, including Alzheimer's and multiple  sclerosis, atherosclerosis, many cancers, and birth defects spina bifida, autism, preterm birth, and fetal alcohol syndrome.  ]

Furthermore, if the amount of ingested methanol were unaffected by such variables as the intervals of drinking, the rate of drinking, excretion and metabolic processes, the mean concentration of methanol after 14 days of drinking would be  8.4 mg/kg of body water.

It is also calculable that the amount of methanol derived from grain alcohol would be undetectable through most days of drinking.

It is suggested, therefore, that the presence of small amounts of methanol in the bourbon may explain a somewhat higher blood methanol level in the bourbon drinkers as compared with the grain alcohol drinkers, but not the maximal amount of methanol accumulated with either beverage.

Therefore, these data suggest that most of the methanol found in the former group of drinkers and virtually all of the methanol found in the latter group is derived from endogenous sources.

Discussion

Accumulation of methanol in blood was detected in all subjects studied during chronic ethanol intake.

Blood methanol levels were only slightly higher in the bourbon drinkers than in the grain alcohol drinkers.

This may be explained by the greater content of methanol in the bourbon (40-55 mg/l) as compared to the grain alcohol used (1 mg/l).

However, the exogenous source of methanol cannot account for the amount of methanol that accumulated in the blood, which suggests that a major fraction, if not all, of the methanol was more than likely derived from endogenous sources.

It remains to be established if the methanol-producing enzyme system described by Axelrod and Daly (1965) is capable of producing quantities of methanol in blood similar to those found in this study.

Data obtained in this study do not eliminate the possibility that methanol may be derived in part from metabolic processes involving intestinal flora.

What are some possible mechanisms which may underlie the accumulation of blood methanol during chronic ethanol ingestion?

Although both ethanol and methanol can be oxidized by catalase and alcohol dehydrogenase, there are differences in the major metabolic pathways which affect the disposition of these two alcohols.

Tephly et al. (1964) showed that the peroxidative system involving hepatic catalase had played a major role in methanol oxidation in the rat.

Kimi and Cooper (1961) found that the alcohol dehydrogenase system and not the catalase-peroxide system was responsible for the physiological oxidation of methanol in the monkey.

These data have been confirmed in subsequent studies by Goodman and Tephly (1968).

In addition, studies of Mani et al. (1970) indicate that human alcohol dehydrogenase oxidizes methanol at approximate 1/10 of the ethanol rate.  [ Thus, the half-life in human blood for methanol is 3 hours, while for ethanol is 1/3 hour. ]

[ Mani JC, Pietruszko R, Theorell H.
Methanol activity of alcohol dehydrogenases from human liver, horse liver, and yeast.
Arch Biochem Biophys. 1970 Sep;140(1):52-9.
PMID: 4318994 ]

The Km values of 6.8X10E-6 M (330 mg/l) and 1.5X10-4 M (91 mg/l) for methanol and ethanol, respectively, found for human liver alcohol dehydrogenase have good correspondence to the noncompetitive concentrations of ethanol found in this study (approximately 200 ml/l).

Since both methanol and ethanol are metabolized by the same enzyme systems, ethanol competitively inhibits the oxidation of methanol, it is likely that methanol accumulates in the blood, because of competitive inhibition of the enzyme which metabolizes both alcohols.

This conclusion is supported by the finding that during the early part of the withdrawal phase, blood methanol levels remained relatively constant until blood ethanol levels declined from approximately 700 to 200 mg/l. 

We also observed that when alcohol consumption was temporarily interrupted or decreased during the phase of continuous drinking (Fig. 4), blood methanol levels remained relatively unaffected if blood ethanol concentrations were above 700 to 200 mg/l.

These findings suggest the enzyme which catalyses the metabolism of both methanol and ethanol is saturated by relatively low concentrations of ethanol.

Our data also indicate that levels of blood methanol are related to the concentrations of blood ethanol with time.

At the present time it is not  possible to define any definitive relationship between the degree of intoxication observed during chronic ethanol ingestion and the accumulation of methanol in blood.

Similarly, it is difficult to determine the contrilbution of methanol catabolism to the alcohol withdrawal syndrome after cessation of alcohol ingestion.

This question can only be answered by careful correlative studies of clinical phenomena and methanol metabolism in alcoholics after a period of experimentally induced alcohol intake and withdrawal.

Such studies are  currently underway in our research ward and laboratory. 

Conclusion

Accumulation of methanol in the blood of alcoholics was detected during long-term voluntary consumption of both bourbon and grain alcohol.

Blood methanol levels are dependent upon time and dose-related concentrations of ethanol, suggesting that it accumulates as a result of competitive inhibition of alcohol dehydrogenase by ethanol.

In both groups of drinkers the blood methanol may be derived in part from endogenous sources.





within the fellowship of service,
Rich Murray
http://rmforall.blogspot.com
Back to Top
 Post Reply Post Reply Page  123>
  Share Topic   

Forum Jump Forum Permissions View Drop Down

Forum Software by Web Wiz Forums® version 10.14
Copyright ©2001-2012 Web Wiz Ltd.
The MS-UK Website | Contact Us
© 2014 MS-UK | Registered Charity No 1033731 | MS-UK Free Advice Line 0800 783 0518