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Ampyra (Fampyra)









Irish HSE to reconsider funding of MS drug Fampyra(19/11/14)

The Irish Health Service Executive has said its drugs committee will meet to reconsider a decision not to fund a life-changing drug for multiple sclerosis patients.

Fampyra, or Fampridine, which is made by Biogen Idec, costs between €220 and €500 for a monthly dose.

Patients were receiving the drug for free until July of this year, but since then they have had to start paying for it themselves.

The drug helps MS patients to walk and walk faster.

It does not work for everyone, but some of the thousand or so patients taking the drug have claimed it has meant the difference between whether they could leave their homes unaided or not.

In May 2013, the HSE decided not to approve the reimbursement of the drug under any of its free schemes as the manufacturer had failed to formally justify the high price it was charging.

Earlier this year, patients stopped getting the drug for free and now have to pay up to €500 for a monthly dose.

The HSE has since had further contact with the makers of the drug.

It has said its drugs committee will reconsider the outcome of its commercial discussions with the manufacturer before the end of next month.

Independent TD Denis Naughten, who raised the plight of MS patients on a number of occasions in the Dáil, has called on the HSE to ensure that the drug is provided under one of its free schemes.

Source: RTÉ News © RTÉ 2014-RTÉ Commercial Enterprises Ltd (19/11/14)

Irish health service executive rejects MS drug Fampridine again(30/10/04)

Decision comes as a blow to patients who are paying up to €500 a month for Fampridine.

The Health Service Executive has rejected a second application from the makers of a drug that helps people with multiple sclerosis to walk to have it covered by State-funded drug schemes.

The decision will come as a blow to MS patients who are paying up to €500 a month for Fampridine (known commercially as Fampyra), which greatly increases mobility among some of those with the condition.

The HSE first rejected the reimbursement of the drug in May 2013, saying the manufacturer, Biogen Idec, had failed to demonstrate or provide any formal justification for the prices it proposed.

Its drugs committee recommended further discussions take place with neurologists about new drugs that are emerging to treat MS, before Fampridine was reconsidered. Discussions with Biogen Idec started again in July and the company said it offered “additional and significant reductions” in price.

However, yesterday the HSE told Independent TD Denis Naughten “the manufacturer has been unable to demonstrate the cost-effectiveness of Fampridine in the Irish healthcare setting”.

“The HSE decision on Fampridine is in line with many other European countries which have also, to date, not provided the drug under their public health systems.”

Mr Naughten said: “Rather than both sides continuing to horse trade on this life-altering drug, I’m proposing that the HSE and the company sit down and let Ireland become a specific pilot to design a roll-out scheme and pricing structure for Fampyra.”

Outlining his proposal Mr Naughten said: “With 8,000 people with MS in Ireland, which is a relatively small cohort, and in light of the fact that the northwest of Ireland has one of the highest incidence of multiple sclerosis in the world, we are in an ideal situation to evaluate which patients can benefit from this drug.

Mr Naughten called on the HSE and the Government to enter direct talks with the manufacturer with the aim of making Ireland a pilot country for rolling out the drug.

The National Centre for Pharmacoeconomics, which rules on the cost-effectiveness of new drugs, found Fampyra would cost nearly €7,000 a patient each year. It said the €20 million annual cost to the State over five years would take money from other areas.

Source: The Irish Times © 2014 The Irish Times (30/10/04)

MS Cannabis drug ‘too costly’ for England but not Wales(08/10/14)

A drug derived from cannabis, which many people with multiple sclerosis say helps ease their symptoms, has been ruled too expensive to be used by the NHS in England even though it is approved for Wales.

In new guidelines for the diagnosis and treatment of people with the disabling disease, the National Institute for Health and Care Excellence (Nice) says the price set by the manufacturer of Sativex (nabiximols) is too high for the benefit it gives patients. But the decision opens up the sort of “postcode lottery” that Nice was set up to end, with MS patients in Wales able to use the drug on the NHS while those in England either have to buy it themselves or go without. Some will use the illegal drug instead.

A second drug, Fampyra (fampridine), designed to improve people’s ability to walk, has been rejected by both England and Wales. Neither drug is routinely available in Scotland.

“The substantial cost of Sativex and fampridine compared to the modest benefit does not justify their use; there are better ways to improve care for people with MS,” said Dr Paul Cooper, a consultant neurologist who chaired the guideline development group.

In a Guardian podcast, he suggested Wales had been “a little naive” in their assessment of Sativex: “They have taken information from the drug company at face value without seeing the original data and they’ve used dosages and potential benefits that we would not agree with.”

But the MS Society’s chief executive, Michelle Mitchell, said the rejection of the two drugs by Nice was disappointing. “Surely we should be striving for the most innovative treatment and care to be made available to people with MS, not limiting options even further,” she said.

The charity published a survey of nearly 4,000 people with MS that found 82% of those taking Sativex considered it essential or a high priority. The main reasons people gave for not taking Sativex were that it was not available where they lived – prior to Nice’s decisions, the NHS makes local decisions about funding the drug – or that they would have to pay privately.

“I experience very painful spasms around my ribs, the MS hug, and tightness in my arms and legs. I’ve been told that Sativex could give me some relief but it seems so out of reach,” said Shona Garrett, 38, from Lowestoft, who was diagnosed two years ago and is on a waiting list for the drug in her area. “I also experience nerve pain like constant pins and needles in my feet, and I’ve heard Sativex could help with this too. No one has offered me any other options.”

She and her husband had discussed paying for the drug privately, but they had been told it would cost £500 a month, which is more than they can afford.

About 100,000 people in the UK have MS. It tends to hit younger people and can lead to serious long-term disability.

The guideline says people with suspected disease should be referred promptly to a consultant neurologist for diagnosis. Among other recommendations are that they should have a single expert to speak to about their care, concerns and treatment options so they are not shuttled about between different doctors and nurses. They should also be encouraged and helped to exercise.

The MS Trust said although it welcomed its publication, “regrettably, we believe that the guideline falls short. Though it contains a number of welcome recommendations, it also contains some significant gaps and omissions. Overall we believe it demonstrates a lack of ambition to provide what people with MS need, that is, a genuinely comprehensive description of best practice in MS care.”

Source: The Guardian © 2014 Guardian News and Media Limited (08/10/14)

Biogen to reapply for Irish HSE funding for MS drug Fampyra(17/06/14)

The makers of a drug that helps people with multiple sclerosis to walk are to make a fresh application to have it covered by the Health Service Executive-funded drug schemes. People with MS, who say Fampridine (known commercially as Fampyra) has greatly increased their mobility, have criticised the HSE for not reimbursing the cost of the drug on the long-term illness scheme.

In 2012, regulatory authorities concluded that Fampyra was not demonstrably cost-effective for the treatment of MS. The HSE said the manufacturers, Biogen Idec, had failed to demonstrate or provide any formal justification of the prices proposed, but did not rule out a revised application.

The National Centre for Pharmaco-economics (NCPE), which rules on the cost-effectiveness of new drugs, said Fampyra would cost nearly €7,000 a patient each year. It said the €20 million annual cost to the State over five years would take money from other areas. Biogen later made the drug available free of charge to some patients as part of a late-stage clinical trial.

Since Fampyra was licensed for sale and became commercially available here this year, Biogen started charging for the product, leaving patients facing a €500 monthly bill to continue treatment.

One of these is Rosaleen Rafter, from Ballina, Co Mayo, whose daughter Caitríona Redmond says it will be impossible for her mother to afford the drug on her pension. Ms Redmond has been running a campaign through Facebook to highlight her mother’s battle to continue getting “the only treatment that has improved and stabilised her symptoms of MS”. “My mum retired early because of the illness and her loss of mobility and loss of power in her arms and hands. She uses a rollator to walk and has a hand-controlled adapted car as her legs have severely reduced power. She has foot drop and has had two falls, one of which took me and my brother ages to get her off the ground and resulted in a fractured shoulder.

“Watching the effects that her condition has on her has been awful and, without her medication, things will progress sooner.”

Last week, Minister of State for Primary Care Alex White told the Dáil he understood Biogen had told the HSE it intended to submit a revised application to the NCPE. The HSE would then reconsider the application “in line with the agreed procedures and timescales for the assessment of new medicines”.

Mr White said he was aware that studies were ongoing to assess the wider impact of the drug on both walking and quality of life for people with MS.

Their results would contribute to the evidence base demonstrating the clinical effectiveness of the product, which could be used to support future applications for inclusion on HSE drugs schemes.

Biogen said it was working with the authorities to make Fampyra available to all patients. It said it provided the drug free for 2½ years to qualifying patients and continued to provide the first four weeks of treatment free, so that patients who responded to it could be identified.

Source: The Irish Times © 2014 THE IRISH TIMES (17/06/14)

MS patients blocked from 'life-changing' drugs Fampyra and Sativex(10/06/14)

People with multiple sclerosis are on the verge of being denied two drugs that help alleviate pain as a result of new NHS recommendations.

Fampyra and Sativex have been licenced in recent years to help people who experience mobility problems and muscle spasms.

However, the National Institute of Health and Care Excellence (NICE) is due to reject the drugs as treatments for MS, with experts saying they are not cost-effective.

In a letter to the Daily Telegraph, a group of experts including the head of the MS Society and seven neurologists say NICE has not taken full account of the "life-changing" differences the two drugs make to sufferers' lives.

"NICE is proposing to block access to two potentially life-changing MS treatments which are licensed and proven to be effective at helping people walk more easily and control painful muscle spasms," they wrote.

"If this guideline remains unchanged, people will be forced to pay privately, or face the agonising daily frustration of living with painful and debilitating symptoms, knowing there are drugs that may help them, but that they can't get access to."

Fampyra helps treat mobility problems, while sativex can be used to treat muscle spasms. On a private prescription, they would cost an MS surferer between £200 and £350.

The experts said NICE has over-estimated how much medication people would need for the drugs to be effective.

It is estimated that of the 100,000 people in the UK with MS, 40,000 would benefit from Fampyra and Sativex.

Michelle Mitchell, chief executive of the MS Society, told the Telegraph: "We understand that NICE has to make difficult decisions which balance cost to the NHS with the efficacy of a given treatment. But we don't understand why NICE deliberately excluded organisations that represent people with MS from a process which resulted in a proposal that two relatively affordable drugs with proven efficacy should be not be used in the NHS."

Willy Notcutt, Consultant in Pain Management at James Paget University Hospital, Norfolk, added: "Many people, including doctors, don't really understand how unpleasant symptoms such as spasms are - for example someone screaming in pain whenever someone tries to wash them.

"For many of them these treatments are invaluable and make life worth living again."

NICE said organisations will have their chance to comment and that the guidelines will be revised if new evidence emerges in support of Fampyra and Sativex.

Source: International Business Times © Copyright 2014 IBTimes Co., Ltd (10/06/14)

Irish concerns over price of multiple sclerosis drug Fampyra(27/05/14)

People with multiple sclerosis will have to pay up to €500 a month for a new drug that could help them walk, after the HSE confirmed Fampyra is not covered under any of its community drugs schemes.

Famprya or fampridine has been licensed in Ireland and became commercially available though pharmacies for the first time this year.

A number of MS patients in Ireland have been using it as part of a late stage clinical trial.

The drug works by helping damaged nerve fibres to conduct messages better by blocking tiny pores on the fibres.

The HSE said its manufacturer, Biogen Idec, does not currently have an arrangement in place for its funding under the community drugs schemes in accordance with the provision of the Health (Pricing and Supply of Medical Goods) Act 2013.

It also said Biogen Idec had failed to demonstrate or provide any formal justification of the prices proposed.

But the executive said it is open to Biogen submitting a new revised application, and would consider any such application in line with the processes formally agreed with the pharmaceutical industry.

HSE clinical lead for the Medicines Management Programme Professor Michael Barry said he will consider including Fampyra under the HSE community drug scheme if there is new evidence to suggest that the drug has a beneficial effect for patients or if Biogen lowers the price.

Speaking on RTÉ's Morning Ireland, Prof Barry said that when the decision was made not to include the MS drug under the scheme in 2012, there was not sufficient evidence to suggest it was successful.

However, he said new evidence may change this decision.

He also said that the drug would cost nearly €7,000 per patient per year which would potentially cost the state €20m over five years.

He suggested that this could take money from other healthcare, such as cancer therapy.

Biogen said it is committed to advancing and supporting MS care in Ireland and "strives to make our therapies available to all patients who need them"

It said it is "committed to working with authorities to ensure people living with MS who qualify for our treatments have access to them."

The company added that it remains committed to understanding the full benefit of Fampyra through continued investment in a clinical trial programme.

Source: RTÉ © RTÉ 2014-RTÉ Commercial Enterprises Ltd (27/05/14)